Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil.
Laboratory of Exercise Biochemistry and Physiology, Department of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil.
Mutagenesis. 2019 May 29;34(2):135-145. doi: 10.1093/mutage/gez001.
Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes. We evaluated 75 patients with type 2 diabetes, registered in the Integrated Clinics of the University of Southern Santa Catarina. Participants received 4000 IU of vitamin D3 (25(OH)D) supplementation daily for 8 weeks. Blood samples were collected at the beginning and at the end of the supplementation, and 4 weeks after the end of supplementation. The glycidic and lipid profiles [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides], oxidative stress, DNA damage and 25(OH)D levels were evaluated. Vitamin D3 supplementation for 8 weeks showed enough to significantly increase blood levels of 25(OH)D. A significant difference in lipid profile was observed only in non-HDL cholesterol. Significant changes were observed in glucose homeostasis (fasting glucose and serum insulin) and, in addition, a reduction in the parameters of oxidative stress and DNA damage. There was a significant reduction in the values of 25(OH)D 4 weeks after the end of the supplementation, but levels still remained above baseline. Use of vitamin D supplementation can be an ally in the health modulation of patients with type 2 diabetes mellitus.
2 型糖尿病在全球范围内的发病率呈上升趋势，现已成为一种流行疾病。2 型糖尿病与维生素 D 缺乏之间存在密切关联。由于维生素 D 对葡萄糖稳态具有有益作用，本研究旨在评估维生素 D3 补充对血糖控制和其他代谢效应的调节作用，以及对 2 型糖尿病患者基因组不稳定性的调节作用。我们评估了 75 例登记在南圣卡塔琳娜联邦大学综合诊所的 2 型糖尿病患者。参与者每天接受 4000 IU 的维生素 D3（25（OH）D）补充，持续 8 周。在补充开始时、结束时以及补充结束后 4 周采集血样。评估了糖化和血脂谱[总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白和甘油三酯]、氧化应激、DNA 损伤和 25（OH）D 水平。8 周的维生素 D3 补充足以显著提高血液 25（OH）D 水平。仅在非高密度脂蛋白胆固醇中观察到脂质谱的显著差异。葡萄糖稳态（空腹血糖和血清胰岛素）发生显著变化，此外，氧化应激和 DNA 损伤参数也有所降低。补充结束后 4 周，25（OH）D 值显著下降，但仍保持在基线以上。使用维生素 D 补充剂可以成为 2 型糖尿病患者健康调节的一种辅助手段。
