1 Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
2 Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Eur J Prev Cardiol. 2019 Jul;26(11):1181-1187. doi: 10.1177/2047487319829310. Epub 2019 Feb 6.
Physical activity may have a protective effect against venous thromboembolism (VTE). The aim of this study was to investigate the association between leisure time physical activity, occupational physical activity, and the risk of VTE in men and women separately.
The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108,025 participants of health examinations between 1985 and 2014. Physical activity data were collected by questionnaire. Participants were followed from health examination to first-time VTE event, death, emigration or the end of the study. All VTE events were validated by reviewing medical records and radiology reports.
During 1,496,669 person-years, 2054 participants experienced VTE. Women who performed leisure time physical activity at least once a week had a lower risk of first-time VTE (hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.71-0.98 after adjustments) compared with women with less or no physical activity. Furthermore, women with high occupational physical activity also had a lower risk of VTE (HR 0.85; 95% CI 0.74-0.98). In men, there was no consistent association between either measure of physical activity and the risk of VTE.
We found an association between increased physical activity and a lower risk of first-time VTE in women.
身体活动可能对静脉血栓栓塞症（VTE）有保护作用。本研究旨在分别探讨男性和女性休闲时间身体活动、职业身体活动与 VTE 风险之间的关系。
这项基于人群的前瞻性静脉血栓栓塞症在瑞典北部（VEINS）队列研究纳入了 1985 年至 2014 年间参加健康检查的 108025 名参与者。身体活动数据通过问卷调查收集。参与者从健康检查开始随访，直到首次发生 VTE 事件、死亡、移民或研究结束。所有 VTE 事件均通过审查病历和放射学报告进行验证。
在 1496669 人年期间，有 2054 名参与者发生了 VTE。与活动量较少或不活动的女性相比，每周至少进行一次休闲时间身体活动的女性首次发生 VTE 的风险较低（调整后危险比（HR）0.83；95%置信区间（CI）0.71-0.98）。此外，职业身体活动量较高的女性发生 VTE 的风险也较低（HR 0.85；95% CI 0.74-0.98）。在男性中，两种身体活动测量方法与 VTE 风险之间均无一致的关联。
我们发现，女性身体活动量增加与首次发生 VTE 的风险降低之间存在关联。
