Geng Yimeng, Zhang Peifen, Pan Yanmeng, Wang Huaizhi, Chen Yi, Lai Jianbo, Hu Shaohua
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.
Department of Psychiatry, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 Mar 7;20:515-522. doi: 10.2147/NDT.S438835. eCollection 2024.
Venous thromboembolism (VTE) poses a significant threat to individuals' health, yet its correlation with mental disorders remains underappreciated. Here, we conducted a retrospective analysis to explore the characteristics of psychiatric patients presenting with VTE.
We retrospectively analyzed psychiatric inpatients with elevated plasma D-dimer levels at the Mental Health Center, First Affiliated Hospital, Zhejiang University School of Medicine, from January 2014 to January 2022. The inclusion criteria comprised comprehensive demographic and clinical profiles, including laboratory and imaging findings.
A cohort of 33 eligible patients was included, with plasma D-dimer levels ranging from 880 to 10,700 μg/L FEU. Significantly higher D-dimer levels were observed in patients diagnosed with severe mental disorders (SMD), such as schizophrenia and bipolar disorder, compared to those with mild mental disorders (MMD), including depression and anxiety disorders (p = 0.007). Furthermore, individuals receiving antipsychotic medications for less than one year exhibited elevated D-dimer levels compared to those on treatment for over one year (p = 0.005). However, normalization of D-dimer levels did not demonstrate a significant association with psychiatric diagnosis or treatment duration (p > 0.05).
Our findings suggest that patients diagnosed with SMD or those undergoing antipsychotic treatment for less than one year may have elevated D-dimer levels, indicating a potential predisposition to VTE severity. This underscores the importance of recognizing VTE risk in individuals with severe mental disorders and warrants further investigation into the impact of antipsychotic treatment duration on thrombotic risk.
静脉血栓栓塞症（VTE）对个人健康构成重大威胁，但其与精神障碍的相关性仍未得到充分认识。在此，我们进行了一项回顾性分析，以探讨出现VTE的精神科患者的特征。
我们回顾性分析了2014年1月至2022年1月在浙江大学医学院附属第一医院精神卫生中心血浆D-二聚体水平升高的精神科住院患者。纳入标准包括全面的人口统计学和临床资料，包括实验室和影像学检查结果。
纳入了33例符合条件的患者，血浆D-二聚体水平为880至10700μg/L FEU。与患有轻度精神障碍（MMD）（包括抑郁症和焦虑症）的患者相比，被诊断患有严重精神障碍（SMD）（如精神分裂症和双相情感障碍）的患者D-二聚体水平显著更高（p = 0.007）。此外，与接受抗精神病药物治疗超过一年的患者相比，接受抗精神病药物治疗少于一年的患者D-二聚体水平升高（p = 0.005）。然而，D-二聚体水平的正常化与精神科诊断或治疗持续时间未显示出显著关联（p > 0.05）。
我们的研究结果表明，被诊断患有SMD的患者或接受抗精神病药物治疗少于一年的患者可能D-二聚体水平升高，这表明其可能易患VTE严重程度。这凸显了认识严重精神障碍患者VTE风险的重要性，并值得进一步研究抗精神病药物治疗持续时间对血栓形成风险的影响。
