Ghorbani Ahmad, Zarvandi Mahdi, Rakhshandeh Hassan
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Endocr Metab Immune Disord Drug Targets. 2019;19(7):1075-1082. doi: 10.2174/1871530319666190206213420.
The aim of this randomized controlled trial was to investigate the effects of a polyherbal compound consisting of Aloe vera, black seed, fenugreek, garlic, milk thistle, and psyllium on diabetic patients with uncontrolled dyslipidemia.
Fifty patients with type 2 diabetes who had dyslipidemia in spite of statin therapy were randomly allocated to two groups: control group (n = 25) receiving a conventional therapy with hypolipidemic and hypoglycemic drugs and intervention group (n = 25) receiving both the conventional therapy and the herbal compound (one sachet twice daily) for 12 weeks. Each sachet contained 300 mg of Aloe vera leaf gel, 1.8 g of black seed, 300 mg of garlic, 2.5 g of fenugreek seed, 1 g of psyllium seed, and 500 mg of milk thistle seed.
The levels of serum triglyceride, total cholesterol, low-density lipoprotein, and HbA1c showed a significant in-group improvement in the intervention group. However, the effects of the herbal compound on fasting blood glucose remained insignificant. The compound had no unwanted effect on the kidney function parameters (urea, creatinine) and serum liver enzymes (alanine aminotransferase and aspartate transaminase).
The tested herbal compound, as an add-on to statin therapy, was effective in lowering the serum lipids in diabetic patients with uncontrolled dyslipidemia.
本随机对照试验旨在研究一种由芦荟、黑种草籽、胡芦巴、大蒜、水飞蓟和车前子组成的多草药复方对血脂控制不佳的糖尿病患者的影响。
50例尽管接受他汀类药物治疗仍患有血脂异常的2型糖尿病患者被随机分为两组：对照组（n = 25）接受降血脂和降血糖药物的常规治疗，干预组（n = 25）接受常规治疗和草药复方（每天两次，每次一袋），为期12周。每袋含有300毫克芦荟叶凝胶、1.8克黑种草籽、300毫克大蒜、2.5克胡芦巴籽、1克车前子籽和500毫克水飞蓟籽。
干预组血清甘油三酯、总胆固醇、低密度脂蛋白和糖化血红蛋白水平在组内有显著改善。然而，草药复方对空腹血糖的影响仍然不显著。该复方对肾功能参数（尿素、肌酐）和血清肝酶（丙氨酸转氨酶和天冬氨酸转氨酶）没有不良影响。
作为他汀类药物治疗的补充，受试草药复方对血脂控制不佳的糖尿病患者降低血脂有效。
