Rashidi Ali Asghar, Heidari Bakavoli Ali Reza, Avan Amir, Aghasizade Malihe, Ghazizadeh Hamideh, Tayefi Maryam, Khayyatzadeh Sayyed Saeid, Ebrahimi Mahmoud, Moohebati Mohsen, Safarian Mohammad, Nematy Mohsen, Sadr-Bazzaz Mostafa, Ferns Gordon A, Ghayour Mobarhan Majid
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Res Health Sci. 2018 Sep 8;18(4):e00426.
Obesity is a major public health problem because of its associated diabetes mellitus and cardiovascular disease. We aimed to explore the relationship between dietary macronutrients and adiposity in a cohort study, representative of the city of Mashhad in northeastern Iran.
A cross-sectional study.
The population sample (9847) derived from Mashhad stroke and heart atherosclerotic disorders (MASHAD: 2010-2020) and was obtained using a stratified-cluster method. The subjects were separated into 4 groups by body mass index status: normal weight, underweight, overweight and obese individuals. Individuals with mean age of 48.33 ±8.26 yr were recruited and anthropometric and biochemical factors were measured in all the subjects. Individual dietary intakes were assessed using 24-h dietary recall Dietplan6. Univariate and multivariate analyses were conducted before and after adjustment for age, gender and energy intake.
Obese individuals were significantly less physically active. They had higher levels of serum fasted lipid profile, hs-CRP, uric acid, and glucose, and blood pressures compared to normal weight individuals (P=0.001). There was a significant difference in the dietary intakes of the groups categorized by obese before adjustment for energy intake in the obese compared to the normal weight group. These differences remained statistically significant for Trans fatty acid (P=0.033), lactose (P=0.009), fructose (P=0.025), glucose (P=0.017), sucrose (P=0.021) and maltose (P=0.015) after adjustment for energy intake.
Our findings demonstrate a significant association between dietary Trans fatty acid and total sugar intake with adiposity in a representative population sample from northeastern Iran.
肥胖因其与糖尿病和心血管疾病相关,是一个主要的公共卫生问题。我们旨在通过一项代表伊朗东北部马什哈德市的队列研究,探讨膳食常量营养素与肥胖之间的关系。
一项横断面研究。
人群样本(9847例)来自马什哈德中风和心脏动脉粥样硬化疾病研究(MASHAD:2010 - 2020),采用分层整群抽样方法获得。根据体重指数状况将受试者分为4组:正常体重、体重过轻、超重和肥胖个体。招募平均年龄为48.33±8.26岁的个体,并测量所有受试者的人体测量学和生化因素。使用24小时饮食回顾Dietplan6评估个体饮食摄入量。在对年龄、性别和能量摄入进行调整前后进行单因素和多因素分析。
肥胖个体的身体活动明显较少。与正常体重个体相比,他们的血清空腹血脂谱、hs-CRP、尿酸和血糖水平以及血压更高(P = 0.001)。在未对肥胖组的能量摄入进行调整之前,按肥胖分类的各组饮食摄入量存在显著差异。与正常体重组相比,在对能量摄入进行调整后,反式脂肪酸(P = 0.033)、乳糖(P = 0.009)、果糖(P = 0.025)、葡萄糖(P = (此处原文有误,可能是P =)0.017)、蔗糖(P = 0.021)和麦芽糖(P = 0.015)的这些差异在统计学上仍然显著。
我们的研究结果表明,在来自伊朗东北部的代表性人群样本中,膳食反式脂肪酸和总糖摄入量与肥胖之间存在显著关联。