铅酸电池厂铅暴露工人血清镁组分的评估

Assessment of Serum Magnesium Fractions in Workers Exposed to Pb from Pb-Battery Plant.

作者信息

Kalahasthi Ravibabu, Tapu Barman

机构信息

Regional Occupational Health Centre (Southern) Bangalore, ICMR complex, Poojanahalli Road, Kannamangala Post, Devanahalli, Bangalore, Karnataka, India.

Regional Occupational Health Centre (Southern) ICMR complex, Poojanahalli Road, Kannamangala Post, Devanahalli, Bangalore, Karnataka, India.

出版信息

J Res Health Sci. 2018 Nov 18;18(4):e00430.

PMID:30728316

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6941638/

Abstract

BACKGROUND

Most of studies assessed the effect of Pb-exposure on serum total magnesium (tMg). The hypomagnesium condition depended on protein concentration in the sample and influence of lifestyle factors. This study assessed the effect of Pb- exposure on serum tMg, corrected Mg (cMg), ionized Mg (iMg), percentage of iMg from tMg, and percentage of iMg from cMg with contemplation of lifestyle factors.

STUDY DESIGN

Case control study.

METHODS

The serum magnesium fractions were assessed in 176 male Pb-exposed workers in the year 2015 at Tamil nadu in India and 80 control subjects with no occupational exposure of Pb. The serum tMg and albumin concentrations were estimated using diagnostic kit methods. Blood lead levels (BLLs) were estimated using atomic absorbtion spectrophotometer method. The fraction of cMg and iMg were calculated from serum tMg and albumin concentration among individual subjects.

RESULTS

The BLLs was significantly (P<0.001) increased in the study group as compared to control. Serum tMg, cMg, iMg, % of iMg from tMg and % of iMg from cMg concentrations were not significantly decreased in the study group as compared to control. Pb-exposure was significantly associated with abnormal frequency distribution of serum iMg (P=0.048) and % of iMg from tMg (P=0.016). Smoking habit was significantly associated with cMg (P=0.039) and % of iMg from cMg concentration (P=0.018). The alcohol consumption was significantly (P=0.049) associated with cMg.

CONCLUSION

The Pb-exposure and lifestyle factor such as smoking and alcohol consumption were associated with alteration of serum magnesium fractions.

摘要

背景

大多数研究评估了铅暴露对血清总镁（tMg）的影响。低镁状况取决于样本中的蛋白质浓度以及生活方式因素的影响。本研究在考虑生活方式因素的情况下，评估了铅暴露对血清tMg、校正镁（cMg）、离子化镁（iMg）、tMg中iMg的百分比以及cMg中iMg的百分比的影响。

研究设计

病例对照研究。

方法

2015年在印度泰米尔纳德邦对176名男性铅暴露工人和80名无铅职业暴露的对照者的血清镁组分进行了评估。使用诊断试剂盒方法估算血清tMg和白蛋白浓度。使用原子吸收分光光度计法估算血铅水平（BLLs）。根据个体受试者的血清tMg和白蛋白浓度计算cMg和iMg的组分。

结果

与对照组相比，研究组的BLLs显著升高（P<0.001）。与对照组相比，研究组的血清tMg、cMg、iMg、tMg中iMg的百分比以及cMg中iMg的百分比浓度没有显著降低。铅暴露与血清iMg的异常频率分布（P=0.048）和tMg中iMg的百分比（P=0.016）显著相关。吸烟习惯与cMg（P=0.039）和cMg浓度中iMg的百分比（P=0.018）显著相关。饮酒与cMg显著相关（P=0.049）。