Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Nat Med. 2019 Feb;25(2):206-211. doi: 10.1038/s41591-019-0345-2. Epub 2019 Feb 6.
Advances in genomics and computing are transforming the capacity for the characterization of biological systems, and researchers are now poised for a precision-focused transformation in the way they prepare for, and respond to, infectious diseases. This includes the use of genome-based approaches to inform molecular diagnosis and individual-level treatment regimens. In addition, advances in the speed and granularity of pathogen genome generation have improved the capability to track and understand pathogen transmission, leading to potential improvements in the design and implementation of population-level public health interventions. In this Perspective, we outline several trends that are driving the development of precision epidemiology of infectious disease and their implications for scientists' ability to respond to outbreaks.
基因组学和计算技术的进步正在改变生物系统特征描述的能力，研究人员现在准备在准备和应对传染病的方式上进行精准聚焦的转变。这包括利用基于基因组的方法来提供分子诊断和个体化治疗方案。此外，病原体基因组生成速度和粒度的提高提高了跟踪和理解病原体传播的能力，从而有可能改进人群层面公共卫生干预措施的设计和实施。在本观点中，我们概述了推动传染病精准流行病学发展的几个趋势及其对科学家应对疫情能力的影响。
