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食源性致病菌的基因组学与微生物食品安全

Genomics of foodborne pathogens for microbial food safety.

机构信息

Food and Drug Administration, Office of Regulatory Science, Division of Microbiology, HFS-712, 5001 Campus Drive, College Park, MD 20740, USA.

Food and Drug Administration, Office of Regulatory Science, Division of Microbiology, HFS-712, 5001 Campus Drive, College Park, MD 20740, USA.

出版信息

Curr Opin Biotechnol. 2018 Feb;49:224-229. doi: 10.1016/j.copbio.2017.11.002. Epub 2017 Nov 21.

Abstract

Whole genome sequencing (WGS) has been broadly used to provide detailed characterization of foodborne pathogens. These genomes for diverse species including Salmonella, Escherichia coli, Listeria, Campylobacter and Vibrio have provided great insight into the genetic make-up of these pathogens. Numerous government agencies, industry and academia have developed new applications in food safety using WGS approaches such as outbreak detection and characterization, source tracking, determining the root cause of a contamination event, profiling of virulence and pathogenicity attributes, antimicrobial resistance monitoring, quality assurance for microbiology testing, as well as many others. The future looks bright for additional applications that come with the new technologies and tools in genomics and metagenomics.

摘要

全基因组测序(WGS)已被广泛用于对食源性致病菌进行详细的特征描述。这些来自多种物种的基因组,包括沙门氏菌、大肠杆菌、李斯特菌、弯曲杆菌和弧菌,为这些病原体的遗传结构提供了重要的见解。许多政府机构、行业和学术界已经利用 WGS 方法开发了食品安全方面的新应用,例如疫情检测和特征描述、来源追踪、确定污染事件的根本原因、毒力和致病性特征分析、抗生素耐药性监测、微生物学测试的质量保证,以及其他许多应用。随着基因组学和宏基因组学新技术和工具的出现,未来还将有更多的应用前景。

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