Pereira Keith
Division of Vascular and Interventional Radiology, Saint Louis University, St. Louis, Missouri.
Semin Intervent Radiol. 2018 Dec;35(5):435-442. doi: 10.1055/s-0038-1676322. Epub 2019 Feb 5.
Peripheral arterial disease (PAD) is a prevalent, morbid, and mortal disease. Claudication represents an early, yet common manifestation of PAD. A clinical history and physical examination combined with an ankle-brachial index can help make a diagnosis of claudication. Due to the polyvascular nature of the underlying atherosclerosis, PAD is often associated with heart disease and stroke. Although health implications of PAD derive from both its limb and cardiovascular manifestations, claudication is life-threatening, less limb-threatening. Medical modification of cardiovascular risk factors and exercise are the cornerstone in the treatment of claudication. Revascularization in claudication is focused at improvement in claudication symptoms and functional status, rather than aggressive attempts at limb salvage. The aim of this article is to summarize the strategies in the treatment of claudication, to serve as a concise and informative reference for physicians who are managing these patients. A framework of the decision-making process in the management of patients with claudication is shown, which can be applied in clinical practice.
外周动脉疾病(PAD)是一种常见、致残且致命的疾病。间歇性跛行是PAD的一种早期但常见的表现。临床病史、体格检查以及踝肱指数有助于诊断间歇性跛行。由于潜在动脉粥样硬化具有多血管性,PAD常与心脏病和中风相关。尽管PAD对健康的影响源于其肢体和心血管表现,但间歇性跛行虽危及生命,但对肢体威胁较小。对心血管危险因素进行医学干预和运动是治疗间歇性跛行的基石。间歇性跛行的血运重建主要旨在改善间歇性跛行症状和功能状态,而非积极尝试挽救肢体。本文旨在总结间歇性跛行的治疗策略,为管理这些患者的医生提供一份简洁且信息丰富的参考资料。文中展示了一个管理间歇性跛行患者的决策过程框架,可应用于临床实践。