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老年主动脉瓣狭窄患者行髋部骨折手术的预后。结果是否提示不同的术后策略?

Outcome in elderly patients with aortic stenosis undergoing hip fracture surgery. Results may suggest a different postoperative strategy?

作者信息

Rostagno Carlo, Ranalli Claudia, Polidori Gianluca, Cartei Alessandro, Boccaccini Alberto, Peris Adriano

机构信息

Dipartimento Medicina Sperimentale e Clinica, Università di Firenze, Firenze, Italy.

SOD Medicina Interna e Postchirurgica, AOU Careggi, Firenze, Italy.

出版信息

Trauma Surg Acute Care Open. 2019 Jan 12;4(1):e000218. doi: 10.1136/tsaco-2018-000218. eCollection 2019.

Abstract

BACKGROUND

Five to ten percent of patients with hip fracture have severe aortic valve stenosis (AS). The aim of the present investigation was to evaluate the impact of AS on early and long-term outcome after surgery for hip fracture.

METHODS

145 patients with AS and 283 consecutive patients without AS (control group) aged >70 years referred to Azienda Ospadaliera Universitaria (AOU) Careggi for hip fracture were included in the study. The endpoints were incidence of postoperative myocardial infarction, 30-day and 1-year mortality, and a composite endpoint (30-day mortality + myocardial infarction).

RESULTS

66 patients had mild, 47 moderate and 32 severe AS according to the European Society of Cardiology guidelines. 30-day mortality was 6.2% in AS and 3.1% in controls. Postoperative non-fatal myocardial infarction and composite endpoint were more frequent in AS than in the control group (8.3% vs 1.1%, p<0.001 and 14.5% vs 4.2%, p<0.001, respectively). The risk was significantly higher for patients with severe AS (28.1%). 1-year mortality in patients with moderate/severe AS was 46% in comparison with 16% in mild AS or in the control group (p<0.001). Coronary disease, atrial fibrillation, age, and aortic gradient were independent predictors of mortality in AS.

DISCUSSION

AS significantly affects postoperative outcome after surgery for hip fracture. Since not infrequently AS is incidentally diagnosed during hospitalization after trauma, which should be the management in these patients after hip surgery? How many might benefit from surgical valve replacement or transcatheter aortic valve replacement? A heart team evaluation may be suggested before discharge for most of these patients.

LEVEL OF EVIDENCE

IV.

摘要

背景

5%至10%的髋部骨折患者患有严重主动脉瓣狭窄(AS)。本研究的目的是评估AS对髋部骨折手术后早期和长期预后的影响。

方法

本研究纳入了145例年龄大于70岁、因髋部骨折转诊至Azienda Ospadaliera Universitaria(AOU)Careggi的AS患者以及283例连续入选的无AS患者(对照组)。观察终点为术后心肌梗死发生率、30天和1年死亡率以及复合终点(30天死亡率+心肌梗死)。

结果

根据欧洲心脏病学会指南,66例患者为轻度AS,47例为中度AS,32例为重度AS。AS组30天死亡率为6.2%,对照组为3.1%。AS组术后非致命性心肌梗死和复合终点的发生率高于对照组(分别为8.3%对1.1%,p<0.001;14.5%对4.2%,p<0.001)。重度AS患者的风险显著更高(28.1%)。中度/重度AS患者的1年死亡率为46%,而轻度AS患者或对照组为16%(p<0.001)。冠心病、心房颤动、年龄和主动脉压差是AS患者死亡率的独立预测因素。

讨论

AS显著影响髋部骨折手术后的预后。由于创伤后住院期间经常偶然诊断出AS,那么这些患者髋部手术后应如何管理?有多少患者可能从外科瓣膜置换或经导管主动脉瓣置换中获益?对于大多数此类患者,建议在出院前进行心脏团队评估。

证据级别

IV级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b14/6340543/4d7b9699e0bc/tsaco-2018-000218f01.jpg

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