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在沙特阿拉伯,使用苯二氮䓬类药物和 Z 类药物治疗成人原发性失眠:一项电子德尔菲研究,以帮助制定临床指南。

Using benzodiazepines and Z-drugs for managing primary insomnia in adults in Saudi Arabia: an e-Delphi study to aid the development of clinical guidelines.

机构信息

Reading School of Pharmacy, University of Reading, Whiteknights, 226, Reading, RG6 6AP, UK.

General Directorate of Medical Services, Ministry of Interior, Olaya, Riyadh, Saudi Arabia.

出版信息

Sleep Breath. 2019 Dec;23(4):1133-1139. doi: 10.1007/s11325-019-01794-7. Epub 2019 Feb 7.

Abstract

PURPOSE

This study aims to obtain consensus statements required for the development of clinical guidelines for the use of benzodiazepines (BZDs) and Z-drugs for the management of primary insomnia in adults in Saudi Arabia.

METHODS

Three rounds of the e-Delphi technique using a Bristol Online Survey (BOS) were conducted between May and August 2018. The Director of the Saudi Sleep Medicine Group helped recruit the country's sleep medicine experts. Snowballing was used to forward invitation emails, information sheets, and the survey to known sleep medicine experts and physicians deemed to be interested in the field. All participants' details were anonymised except to the researcher.

RESULTS

Fifteen experts from four different regions and specialities in Saudi Arabia participated in Round 1. Twenty-one statements originated from participants' responses. In Round 2, there were 17 respondents and 16 of the statements obtained the required consensus of 70% or higher. Eleven experts participated in Round 3 and eight statements received 100% agreement, two received 91%, and six received 82%. Having obtained the required consensus of 80% or higher in Round 3, these 16 statements fulfilled the criteria to be included in future guidelines. The five statements that failed to attain the required consensus were rejected as inappropriate for inclusion in Saudi Arabian clinical guidelines.

CONCLUSIONS

The items that achieved the required consensus can be included in future guidelines for the use of BZDs and Z-drugs in the treatment of primary insomnia in adults to standardize best practices in sleep medicine in Saudi Arabia.

摘要

目的

本研究旨在达成共识声明,为制定沙特阿拉伯成人原发性失眠管理中苯二氮䓬类药物(BZDs)和 Z 类药物使用的临床指南提供依据。

方法

2018 年 5 月至 8 月期间采用布里斯托在线调查(BOS)进行了三轮电子德尔菲技术研究。沙特睡眠医学集团主任协助招募了该国的睡眠医学专家。采用滚雪球的方式将邀请电子邮件、信息表和调查转发给已知的睡眠医学专家和有兴趣参与该领域的医生。除研究人员外,所有参与者的详细信息均匿名。

结果

15 名来自沙特阿拉伯四个不同地区和专业的专家参加了第一轮。21 项陈述源自参与者的回复。在第二轮中,有 17 名受访者,其中 16 项陈述获得了 70%或更高的共识要求。11 名专家参加了第三轮,其中 8 项陈述获得了 100%的一致同意,2 项获得了 91%的一致同意,6 项获得了 82%的一致同意。在第三轮中获得了 80%或更高的共识要求后,这 16 项陈述符合纳入未来指南的标准。未能达到所需共识的 5 项陈述被拒绝,认为不适合纳入沙特阿拉伯临床指南。

结论

达到共识要求的项目可以纳入未来成人原发性失眠治疗中使用 BZDs 和 Z 类药物的指南中,以规范沙特阿拉伯睡眠医学中的最佳实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee36/6867977/796dc0cd3077/11325_2019_1794_Fig1_HTML.jpg

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