DeCoste Ryan, Moss Phillip, Boutilier Robert, Walsh Noreen M G
Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), Halifax, Nova Scotia, Canada.
Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.
J Cutan Pathol. 2019 Jun;46(6):425-430. doi: 10.1111/cup.13437. Epub 2019 Mar 28.
Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. From a microscopic perspective, care must be taken to exclude a collision tumor as well as other combined cutaneous neoplasms featuring squamous and glandular differentiation. Direct continuity between the two epithelial phenotypes helps to establish the correct diagnosis and generates interesting speculation about the pathogenesis of these and other epithelial skin tumors. We describe a case of BD in continuity with an invasive adenocarcinoma exhibiting mucinous sweat gland differentiation on the face of an elderly man. Details of the case are outlined with the objective of adding to a scant literature on this topic.
具有附属器分化差异的鲍温病（BD）是一种罕见的复合性皮肤肿瘤，具有不同的表型成分。在这种情况下，已描述了皮脂腺、汗孔样和外毛根鞘样浸润成分，关于黏液性腺样分化的报道极为罕见。临床上，这些肿瘤若无组织病理学评估则没有足够的特征可识别。从显微镜角度来看，必须注意排除碰撞瘤以及其他具有鳞状和腺性分化的复合性皮肤肿瘤。两种上皮表型之间的直接连续性有助于确立正确诊断，并引发了对这些及其他上皮性皮肤肿瘤发病机制的有趣推测。我们描述了一例发生于一名老年男性面部的与具有黏液性汗腺分化的浸润性腺癌相连续的鲍温病病例。现将该病例细节列出，目的是补充关于该主题的少量文献。
