Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, FL, USA.
EuroMov, University of Montpellier, Montpellier, France.
Int J Geriatr Psychiatry. 2019 Jun;34(6):863-867. doi: 10.1002/gps.5081. Epub 2019 Mar 21.
Verbal fluency is a common neuropsychological test that is impaired in dementia. We test whether verbal fluency is a prospective risk factor for incident dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia.
Participants (N = 18 189) from the Health and Retirement Study were administered a standard test of verbal fluency and were assessed for cognitive status every 2 years between baseline and 6 years' follow-up.
Every standard deviation increase in verbal fluency was associated with an approximately 60% reduced risk of incident dementia, an approximately 25% reduced risk of incident CIND, and an approximately 25% reduced risk of conversion from CIND to dementia. These associations were independent of age, gender, education, race, ethnicity, and APOE risk status. The associations were slightly weaker (but still significant) for African Americans and individuals with lower education. There was no interaction between verbal fluency and APOE risk status.
Verbal fluency is an easily administered task that is predictive of incident cognitive impairment.
语言流畅性是一种常见的神经心理学测试，在痴呆症中受损。我们测试语言流畅性是否是痴呆症、认知障碍但非痴呆症（CIND）以及从 CIND 转化为痴呆症的潜在风险因素。
来自健康与退休研究的参与者（N=18189）接受了语言流畅性的标准测试，并在基线和 6 年随访期间每 2 年评估一次认知状态。
语言流畅性每增加一个标准差，与新发痴呆症的风险降低约 60%、新发 CIND 的风险降低约 25%以及从 CIND 转化为痴呆症的风险降低约 25%相关。这些关联独立于年龄、性别、教育程度、种族、民族和 APOE 风险状况。对于非裔美国人和受教育程度较低的个体，这些关联略弱（但仍具有统计学意义）。语言流畅性和 APOE 风险状况之间没有相互作用。
语言流畅性是一种易于管理的任务，可预测认知障碍的发生。
