Gallucci Maurizio, Di Battista Maria Elena, Battistella Giuseppe, Falcone Chiara, Bisiacchi Patrizia Silvia, Di Giorgi Enrico
a Cognitive Impairment Center , Local Health Authority n. 2 Marca Trevigiana , Treviso , Italy.
b Health Districts of Treviso , Local Health Authority n. 2 Marca Trevigiana , Treviso , Italy.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2018 Jul;25(4):550-560. doi: 10.1080/13825585.2017.1349869. Epub 2017 Jul 18.
Most of the studies about conversion from Mild cognitive impairment (MCI) to dementia have focused on amnestic MCI (aMCI) which is considered a preclinical phase of Alzheimer's disease. The aim of the present study was to identify neuropsychological tools that would best predict conversion from aMCI to dementia. Fifty-five aMCI subjects on the Treviso Dementia Registry were investigated. They underwent a neuropsychological evaluation during their first assessment and again at follow-up. Cox proportional-hazard regression models were created to measure the association between the dependent variable (dementia diagnosis or MCI status maintenance) and the neuropsychological test scores at baseline. The sample (28 women and 27 men; mean age 76.82 ± 5.88 years; education 7.62 ± 3.99 years) was observed for an average time of 2.17 ± 1.25 years. A Cox backward stepwise regression showed that the Rey Auditory Verbal Learning Test, Delayed Recall (p = .041) and Semantic Verbal Fluency tests (p = .031) appear to be useful in predicting conversion to dementia.
大多数关于从轻度认知障碍（MCI）转变为痴呆症的研究都集中在遗忘型MCI（aMCI）上，它被认为是阿尔茨海默病的临床前期阶段。本研究的目的是确定最能预测从aMCI转变为痴呆症的神经心理学工具。对特雷维索痴呆症登记处的55名aMCI受试者进行了调查。他们在首次评估时接受了神经心理学评估，并在随访时再次接受评估。创建了Cox比例风险回归模型，以测量因变量（痴呆症诊断或MCI状态维持）与基线时神经心理学测试分数之间的关联关系。对样本（28名女性和27名男性；平均年龄76.82±5.88岁；受教育年限7.62±3.99年）进行了平均2.17±1.25年的观察。Cox向后逐步回归显示，雷伊听觉词语学习测验、延迟回忆（p = 0.041）和语义词语流畅性测验（p = 0.031）似乎有助于预测向痴呆症的转变。
