Ingles Janet L, Wentzel Carolyn, Fisk John D, Rockwood Kenneth
School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada.
Stroke. 2002 Aug;33(8):1999-2002. doi: 10.1161/01.str.0000024433.36590.1b.
Vascular cognitive impairment that does not fulfill dementia criteria (ie, vascular cognitive impairment, no dementia [CIND]) is common. Although progression to dementia is frequent, little is known about factors that predict progression. We examined whether performance on neuropsychological tests administered at baseline could predict incident cases of dementia in patients with vascular CIND after 5 years. Summary of Report- The Canadian Study of Health and Aging is a prospective, cohort study of 10 263 randomly selected persons aged > or =65 years. Of 149 people diagnosed with vascular CIND, 125 completed a battery of neuropsychological tests at baseline. Follow-up cognitive diagnoses were available for 102 individuals. After 5 years, 45 patients (44%) developed dementia. Low baseline scores on tests of memory and category fluency were associated with incident dementia.
Neuropsychological measures can indicate risk of dementia in patients with vascular CIND. This study did not suggest a prediction-to-progression profile distinct from that seen in Alzheimer disease.
不符合痴呆症标准的血管性认知障碍（即血管性认知障碍，无痴呆症[CIND]）很常见。尽管进展为痴呆症很频繁，但对于预测进展的因素知之甚少。我们研究了基线时进行的神经心理学测试表现是否能预测5年后血管性CIND患者的痴呆症发病情况。报告摘要——加拿大健康与老龄化研究是一项对10263名年龄≥65岁的随机选择人员进行的前瞻性队列研究。在149名被诊断为血管性CIND的人中，125人在基线时完成了一系列神经心理学测试。对102人进行了随访认知诊断。5年后，45名患者（44%）发展为痴呆症。记忆测试和类别流畅性测试的低基线分数与痴呆症发病相关。
神经心理学测量可以表明血管性CIND患者患痴呆症的风险。这项研究没有表明与阿尔茨海默病不同的预测进展模式。
