Department of Chemical Sciences, Università di Padova, Via Marzolo 1, 35131, Padova, Italy.
Food and Drug Department, Università di Parma, Parco Area delle Scienze 27/A, 43124, Parma, Italy.
Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3264-3266. doi: 10.1002/anie.201812964. Epub 2019 Feb 7.
Touched for the very first time! It is herein highlighted how acetaldehyde silyl enol ethers undergo enantioselective Mukaiyama aldol reaction with aliphatic and aromatic aldehydes. The chemistry relies on the use of the highly efficient and substrate-selective imidodiphosphorimidate catalyst, which displays some of the features of enzymatic catalysis.
这是首次报道！本文详细介绍了乙醛硅基烯醇醚与脂肪族和芳香族醛的对映选择性 Mukaiyama 缩合反应。该反应依赖于高效、底物选择性的亚氨基二磷酸酯催化剂的使用，该催化剂具有一些酶催化的特点。
