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磁场强度对 Gafchromic EBT-3 薄膜响应的影响。

The effect of magnetic field strength on the response of Gafchromic EBT-3 film.

机构信息

National Physical Laboratory, Chemical, Medical and Environmental Science Department, Teddington, United Kingdom. Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Author to whom correspondence should be addressed.

出版信息

Phys Med Biol. 2019 Mar 14;64(6):06NT03. doi: 10.1088/1361-6560/ab0503.

Abstract

With the advent of MRI-guided radiotherapy, the suitability of commercially available radiation dose detectors needs to be assessed. The aim of this study was to investigate the effect of the magnetic field (B-field) on the response of the Gafchromic EBT-3 films. Moreover, as an independent study, we contribute to clarifying the inconsistency of the results of recent published studies, on the effect of B-field on the sensitivity of Gafchromic films. A Co beam was used to irradiate film samples in an electromagnet. An in-house PMMA phantom was designed to fit in the 5 cm gap between the two poles of the magnet. The phantom consists of two symmetrical plates where a film can be inserted. The absorbed dose rate of the Co beam for zero B-field was measured using alanine pellets in a Farmer-type holder. A 12-point response curve was created, representing [Formula: see text] as a function of dose, for each of five different B-field strengths (0 T to 2 T). This study finds that there is at most a small effect of the magnetic field on the response of EBT-3 film. In terms of netOD (red channel) the change in response varied from ‒0.0011 at 0.5 T to 0.0045 at 2.0 T, with a standard uncertainty of 0.0030. If uncorrected, this would lead to an error in film-measured dose, for the red channel, of 2.4% at 2 T, with a standard uncertainty on dose of 1.4%. Results are also presented for B-field strengths of 0.5 T, 1 T and 1.5 T, which are all zero within the measurement uncertainty. Comparison between other studies is also presented. Considering the small change on dose determined with EBT-3 when irradiated under the presence of B-field and taking into account the overall uncertainty in dosimetry using EBT-3 film achieved in this work, EBT-3 is assessed to be a suitable detector for relative and absolute dosimetry, with appropriate corrections, in MRI-guided radiotherapy. The results of the current work also elucidate the inconsistency on the reports from previous studies and demonstrate the necessity of similar investigations by independent teams, especially if the existing results may be in conflict.

摘要

随着 MRI 引导放疗的出现,需要评估市售辐射剂量探测器的适用性。本研究旨在研究磁场 (B 场) 对 Gafchromic EBT-3 胶片响应的影响。此外,作为一项独立研究,我们有助于澄清最近发表的研究中关于 B 场对 Gafchromic 胶片灵敏度影响的结果不一致性。使用 Co 束在电磁体中辐照胶片样品。设计了一个内部 PMMA 体模,以适合磁铁两极之间的 5cm 间隙。体模由两个对称的板组成,其中可以插入胶片。在零 B 场下,使用 Farmer 型夹具中的丙氨酸小球测量 Co 束的吸收剂量率。为每个 5 种不同 B 场强度(0T 至 2T)创建了 12 点响应曲线,代表[公式:见文本]作为剂量的函数。本研究发现磁场对 EBT-3 胶片的响应仅有很小的影响。就净 OD(红色通道)而言,响应变化从 0.5T 时的-0.0011 到 2.0T 时的 0.0045,标准不确定度为 0.0030。如果未校正,这将导致红色通道胶片测量剂量的误差为 2.0T 时为 2.4%,剂量标准不确定度为 1.4%。还给出了 0.5T、1T 和 1.5T 的 B 场强度的结果,这些结果在测量不确定度内均为零。还介绍了其他研究的比较。考虑到在存在 B 场的情况下辐照时用 EBT-3 确定的剂量变化很小,并考虑到本工作中使用 EBT-3 胶片实现的放射剂量测量的整体不确定性,评估 EBT-3 是一种适合 MRI 引导放疗的相对和绝对剂量测量的合适探测器,需要进行适当的校正。当前工作的结果还阐明了先前研究报告的不一致性,并证明了特别是如果现有结果可能存在冲突,独立团队进行类似研究的必要性。

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