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EBT型放射变色薄膜在放射治疗中的临床应用。

Clinical use of EBT model Gafchromic film in radiotherapy.

作者信息

Fiandra Christian, Ricardi Umberto, Ragona Riccardo, Anglesio Silvia, Giglioli Francesca Romana, Calamia Elisa, Lucio Francesco

机构信息

Radiation Oncology Department, University of Turin, Turin, Italy.

出版信息

Med Phys. 2006 Nov;33(11):4314-9. doi: 10.1118/1.2362876.

Abstract

The Gafchromic EBT was recently introduced in film dosimetry for external beam therapy (EBT). The high spatial resolution, weak energy dependence, and near-tissue equivalence of EBT films make them suitable for measurement of dose distributions in radiotherapy, especially intensity-modulated radiation therapy (IMRT). Starting with a sensitometric curve and dose uncertainty relative to the flatbed scanner, the goal of this study was to find an efficient method of correcting for light scattering, and to compare dose distribution supplied by Gafchromic EBT with the distribution obtained with a 2D ion-chamber detector system. Light scattering was analyzed for different levels of dose, and was found to depend on the red-scale value as well as the position of the pixel on the scanner. Many "uniform" films were exposed at different levels of dose to create a two-dimensional matrix correction to take this effect into account. The dose distribution obtained for three clinical beams (10 x 10, 15 x 15 cm open fields and 12 x 12 cm wedge 60 degrees field) were in agreement with those supplied by the 2D array. Gamma index <1 (using 5 mm distance and 5% dose as constraints) for the three fields considered was reached in an average of 98% of the points.

摘要

Gafchromic EBT最近被引入用于外照射治疗(EBT)的胶片剂量测定。EBT胶片具有高空间分辨率、弱能量依赖性和接近组织等效性,使其适用于放射治疗中剂量分布的测量,尤其是调强放射治疗(IMRT)。从感光曲线和相对于平板扫描仪的剂量不确定性出发,本研究的目的是找到一种校正光散射的有效方法,并将Gafchromic EBT提供的剂量分布与二维电离室探测器系统获得的分布进行比较。分析了不同剂量水平下的光散射,发现其取决于红色刻度值以及像素在扫描仪上的位置。在不同剂量水平下曝光了许多“均匀”胶片,以创建二维矩阵校正来考虑这种效应。对三个临床射野(10×10、15×15 cm开放野和12×12 cm 60度楔形野)获得的剂量分布与二维阵列提供的分布一致。在所考虑的三个射野中,平均98%的点达到了伽马指数<1(使用5 mm距离和5%剂量作为约束条件)。

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