Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
J Trace Elem Med Biol. 2019 Mar;52:216-221. doi: 10.1016/j.jtemb.2019.01.002. Epub 2019 Jan 4.
Several studies have investigated serum zinc levels in patients with polycystic ovarian syndrome (PCOS), but the results of these studies remain inconclusive. Therefore, to derive a more precise estimation, we conducted a meta-analysis to investigate serum zinc concentrations in women with PCOS in comparison with healthy subjects. Electronic search was performed in PubMed, Scopus, and Google scholar up to April; 4, 2018 without any restriction. Eligible studies that evaluated the levels of zinc status in subjects with PCOS were included. Weighted mean differences (WMDs) with corresponding 95% CIs in serum zinc levels were initially estimated using a random-effects model. Eight studies, measuring circulating zinc levels in 552 PCOS and 464 control subjects, were included. Pooled effect size suggested that serum zinc levels in women with PCOS were not statistically different than their controls (WMD = -4.43 mg/dL; 95% CI = [-10.30, 1.44]; P = 0.139). Exclusion of one study revealed that women with PCOS significantly have lower serum zinc levels compared to healthy controls (WMD: -6.60 mg/dL; 95% CI = [-12.43, -0.76], P = 0.027). Our study indicated that circulating zinc levels in women with PCOS were significantly lower than those in healthy controls when detailed analysis is conducted. Large scale studies are needed to elucidate clear relation between zinc status and etiology of PCOS.
已有多项研究调查了多囊卵巢综合征（PCOS）患者的血清锌水平，但这些研究的结果仍不确定。因此，为了得出更准确的估计，我们进行了一项荟萃分析，以调查 PCOS 患者与健康受试者的血清锌浓度。电子检索 PubMed、Scopus 和 Google Scholar，截至 2018 年 4 月 4 日，无任何限制。纳入评估 PCOS 患者锌状态水平的合格研究。使用随机效应模型初步估计血清锌水平的加权均数差（WMD）及其相应的 95%置信区间。共纳入 8 项研究，测量 552 例 PCOS 和 464 例对照者的循环锌水平。汇总效应量表明，PCOS 妇女的血清锌水平与对照组无统计学差异（WMD = -4.43mg/dL；95%CI = [-10.30，1.44]；P = 0.139）。排除一项研究后发现，与健康对照组相比，PCOS 妇女的血清锌水平显著降低（WMD：-6.60mg/dL；95%CI = [-12.43，-0.76]，P = 0.027）。我们的研究表明，当进行详细分析时，PCOS 妇女的循环锌水平明显低于健康对照组。需要进行大规模研究以阐明锌状态与 PCOS 病因之间的明确关系。
