Bizoń Anna, Tchórz Agata, Madej Paweł, Leśniewski Marcin, Wójtowicz Mariusz, Piwowar Agnieszka, Franik Grzegorz
Department of Toxicology/Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wrocław, Poland.
Students Scientific Society at the Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wrocław, Poland.
J Clin Med. 2022 May 1;11(9):2548. doi: 10.3390/jcm11092548.
Superoxide dismutase (SOD) is a crucial antioxidant enzyme involved in the antioxidant pathway during both normal cellular metabolism and different pathologic processes. We investigated the activity of the copper (Cu)-zinc (Zn) SOD1 as well as the level of Cu and Zn in the serum of women with polycystic ovary syndrome (PCOS) and control group. Moreover, the prevalence of rs2070424 gene polymorphism of the enzyme in the course of PCOS was evaluated. Significantly lower activity of SOD 1 and Cu, Zn concentration was found in the group of women with PCOS than without the syndrome. Insulin resistance in the group of women with PCOS caused a further SOD1 activity decrease, while Cu concentration and the value of Cu/Zn was increased when compared to women with normal insulin levels. Furthermore, we assessed for the first time the rs2070424 polymorphism of SOD1 in the women with PCOS, and in these patients we detected dominant variant AA (93.3%). Due to a small number of other genotypes, it is difficult to state if lower SOD1 activity was strictly associated with the AA variant or if other factors play a crucial role, but this should be taken into account.
超氧化物歧化酶（SOD）是一种关键的抗氧化酶，在正常细胞代谢和不同病理过程中均参与抗氧化途径。我们研究了多囊卵巢综合征（PCOS）女性和对照组血清中铜（Cu）-锌（Zn）超氧化物歧化酶1（SOD1）的活性以及铜和锌的水平。此外，还评估了该酶的rs2070424基因多态性在PCOS病程中的发生率。发现PCOS女性组的SOD1活性以及铜、锌浓度显著低于无该综合征的女性组。与胰岛素水平正常的女性相比，PCOS女性组的胰岛素抵抗导致SOD1活性进一步降低，而铜浓度和铜/锌值升高。此外，我们首次评估了PCOS女性中SOD1的rs2070424多态性，在这些患者中检测到显性变体AA（93.3%）。由于其他基因型数量较少，很难确定较低的SOD1活性是否与AA变体严格相关，或者其他因素是否起关键作用，但这一点应予以考虑。
