动态对比增强 MRI 揭示了正常大脑中海马中的独特血脑屏障通透性特征。
Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.
机构信息
From the Department of Radiology (J.I.), Weill Cornell Medicine, New York New York
The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases (M.M., C.A., B.D.).
出版信息
AJNR Am J Neuroradiol. 2019 Mar;40(3):408-411. doi: 10.3174/ajnr.A5962. Epub 2019 Feb 7.
Abstract
We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
摘要
我们报告了 5 名健康受试者的前瞻性动态对比增强磁共振成像分析，以研究特定区域的血脑屏障通透性。通过标准化的后处理和 ROI 采样方法，基于模型定量的结果显示，海马区的动态对比增强曲线下面积显著升高，血脑屏障通透性指标（体积转移常数和血管外细胞外空间体积）也显著增加。这些发现表明海马区存在独特的血脑屏障通透性特征，与先前的动物研究结果一致，这可能为未来评估海马区病理起作用的患者群体的研究奠定基础。
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