From the Department of Radiology (J.I.), Weill Cornell Medicine, New York New York
The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases (M.M., C.A., B.D.).
AJNR Am J Neuroradiol. 2019 Mar;40(3):408-411. doi: 10.3174/ajnr.A5962. Epub 2019 Feb 7.
We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
我们报告了 5 名健康受试者的前瞻性动态对比增强磁共振成像分析，以研究特定区域的血脑屏障通透性。通过标准化的后处理和 ROI 采样方法，基于模型定量的结果显示，海马区的动态对比增强曲线下面积显著升高，血脑屏障通透性指标（体积转移常数和血管外细胞外空间体积）也显著增加。这些发现表明海马区存在独特的血脑屏障通透性特征，与先前的动物研究结果一致，这可能为未来评估海马区病理起作用的患者群体的研究奠定基础。
