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Serendipity: decitabine monotherapy induced complete molecular response in a 77-year-old patient with acute promyelocytic leukemia.意外发现：地西他滨单药治疗使一名77岁急性早幼粒细胞白血病患者出现完全分子反应。
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Successful treatment of a patient with acute promyelocytic leukemia with a STAT5B/RARA fusion gene using decitabine.使用地西他滨成功治疗一名患有STAT5B/RARA融合基因的急性早幼粒细胞白血病患者。
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Current treatment of acute promyelocytic leukemia.急性早幼粒细胞白血病的当前治疗方法。
Haematologica. 2007 Mar;92(3):289-91. doi: 10.3324/haematol.11226.
8
Acute promyelocytic leukemia: new issues on pathogenesis and treatment response.急性早幼粒细胞白血病：发病机制与治疗反应的新问题
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Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia.新诊断的急性早幼粒细胞白血病患者使用三氧化二砷实现分子缓解。
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Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study.三氧化二砷和伊达比星诱导复发的急性早幼粒细胞白血病缓解：一项初步研究的临床病理及分子特征
Am J Hematol. 2001 Apr;66(4):274-9. doi: 10.1002/ajh.1057.

引用本文的文献

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Clinical Response to Venetoclax and Decitabine in Acute Promyelocytic Leukemia With a Novel RARA-THRAP3 Fusion: A Case Report.新型RARA-THRAP3融合基因的急性早幼粒细胞白血病对维奈克拉和地西他滨的临床反应：一例报告
Front Oncol. 2022 Feb 7;12:828852. doi: 10.3389/fonc.2022.828852. eCollection 2022.

本文引用的文献

1
The forkhead box C1 (FOXC1) transcription factor is downregulated in acute promyelocytic leukemia.叉头框C1（FOXC1）转录因子在急性早幼粒细胞白血病中表达下调。
Oncotarget. 2017 Sep 20;8(48):84074-84085. doi: 10.18632/oncotarget.21101. eCollection 2017 Oct 13.
2
Successful treatment of a patient with acute promyelocytic leukemia with a STAT5B/RARA fusion gene using decitabine.使用地西他滨成功治疗一名患有STAT5B/RARA融合基因的急性早幼粒细胞白血病患者。
Leuk Lymphoma. 2018 Mar;59(3):763-765. doi: 10.1080/10428194.2017.1357176. Epub 2017 Aug 1.
3
Molecular Characteristics and Clinical Significance of 12 Fusion Genes in Acute Promyelocytic Leukemia: A Systematic Review.急性早幼粒细胞白血病中12种融合基因的分子特征及临床意义：一项系统综述
Acta Haematol. 2016;136(1):1-15. doi: 10.1159/000444514. Epub 2016 Apr 19.
4
Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.初发及复发急性早幼粒细胞白血病的全面突变分析
Leukemia. 2016 Aug;30(8):1672-81. doi: 10.1038/leu.2016.69. Epub 2016 Apr 11.
5
Microgranular acute promyelocytic leukemia presenting with leukopenia and an unusual immunophenotype.表现为白细胞减少和异常免疫表型的微颗粒型急性早幼粒细胞白血病。
Hematol Oncol Stem Cell Ther. 2017 Mar;10(1):35-38. doi: 10.1016/j.hemonc.2015.12.004. Epub 2016 Jan 16.
6
STAT3 signaling pathway is involved in decitabine induced biological phenotype regulation of acute myeloid leukemia cells.信号转导与转录激活因子3（STAT3）信号通路参与了地西他滨诱导的急性髓系白血病细胞生物学表型调控。
Am J Transl Res. 2015 Oct 15;7(10):1896-907. eCollection 2015.
7
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.全反式维甲酸和三氧化二砷联合治疗急性早幼粒细胞白血病。
N Engl J Med. 2013 Jul 11;369(2):111-21. doi: 10.1056/NEJMoa1300874.
8
The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia.DNA去甲基化剂地西他滨激活TRAIL途径并诱导急性髓性白血病细胞凋亡。
Biochim Biophys Acta. 2013 Jan;1832(1):114-20. doi: 10.1016/j.bbadis.2012.10.001. Epub 2012 Oct 6.
9
Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008.急性早幼粒细胞白血病：1975-2008 年美国基于人群的发病率和生存研究。
Cancer. 2012 Dec 1;118(23):5811-8. doi: 10.1002/cncr.27623. Epub 2012 Jun 15.
10
[Decitabine inhibits cell proliferation and induces apoptosis of all-trans retinoid acid-resistant acute promyelocytic leukemia NB4-R2 cell line].地西他滨抑制全反式维甲酸耐药的急性早幼粒细胞白血病NB4-R2细胞系的细胞增殖并诱导其凋亡
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):48-52.

Serendipity: decitabine monotherapy induced complete molecular response in a 77-year-old patient with acute promyelocytic leukemia.

作者信息

Abboud Ramzi, Han Se Young, Duncavage Eric J, Cashen Amanda F, Shirai Cara Lunn, Welch John S, DiPersio John F, Abboud Camille N

机构信息

BMT and Leukemia Program, Department of Medicine, Washington University School of Medicine, Saint Louis, MO.

Hematology, Oncology, and Transplantation Division, Department of Medicine, University of Minneapolis, MN, USA.

出版信息

Haematologica. 2019 Apr;104(4):e170-e173. doi: 10.3324/haematol.2018.209478. Epub 2019 Feb 7.

DOI:10.3324/haematol.2018.209478
PMID:30733274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6442953/
Abstract
摘要