一名诊断为淋巴结边缘区B细胞淋巴瘤且存在涉及[具体部位1]和[具体部位2]的t(2;14)(p24;q32)的患者。 （注：原文中“involving and.”部分缺失具体内容）
A patient with a diagnosis of nodal marginal zone B-cell lymphoma and a t(2;14)(p24;q32) involving and .
作者信息
Brown Angela, Sciascia-Visani Isabella, Farrell Dianna, Smith Meg, Felix Clive, Mutharajah Vanaja, Ruell Jackie, Taylor Graeme
机构信息
1Genetic Services, Wellington Hospital, Riddiford St, Newtown, Wellington, 6021 New Zealand.
2Department of Pathology, Wellington Hospital, Riddiford St, Newtown, Wellington, 6021 New Zealand.
出版信息
Mol Cytogenet. 2019 Feb 1;12:3. doi: 10.1186/s13039-019-0419-3. eCollection 2019.
BACKGROUND
Nodal marginal zone B-cell lymphoma is a rare entity in which the cytogenetic findings are not well defined. The t(2;14)(p24;q32) has previously been reported in three patients with blastic mantle cell lymphoma and one patient with follicular lymphoma. This rearrangement has not been reported previously in a patient with a diagnosis of nodal marginal zone B-cell lymphoma.
CASE PRESENTATION
We present a male patient who presented with lymphadenopathy. On the basis of his clinicoradiologic presentation, morphological appearances, immunophenotype and molecular findings he was determined to have a diagnosis of nodal marginal zone B-cell lymphoma. Cytogenetic analysis demonstrated a t(2;14)(p24;q32). Further FISH testing showed this rearrangement to involve the and genes.
CONCLUSIONS
We present the first patient with a diagnosis of nodal marginal zone B-cell lymphoma with a t(2;14)(p24;q32). This rearrangement has been described in three other patients who have had a diagnosis of lymphoma. Our findings suggest this rearrangement is not specific to mantle cell lymphoma or follicular lymphoma. The number of cases described are still too low to draw firm conclusions regarding the nature of this rearrangement. In order to refine the clinical and prognostic picture of this finding, publication of further cases is required.
背景
结内边缘区B细胞淋巴瘤是一种罕见的疾病，其细胞遗传学特征尚未明确界定。此前曾有3例母细胞性套细胞淋巴瘤患者和1例滤泡性淋巴瘤患者报道过t(2;14)(p24;q32)。此前尚未有诊断为结内边缘区B细胞淋巴瘤的患者出现这种重排的报道。
病例介绍
我们报告一名出现淋巴结病的男性患者。根据其临床放射学表现、形态学特征、免疫表型和分子学结果，他被诊断为结内边缘区B细胞淋巴瘤。细胞遗传学分析显示为t(2;14)(p24;q32)。进一步的荧光原位杂交检测表明这种重排涉及 和 基因。
结论
我们报告了首例诊断为结内边缘区B细胞淋巴瘤且伴有t(2;14)(p24;q32)的患者。这种重排在另外3例诊断为淋巴瘤的患者中也有描述。我们的研究结果表明这种重排并非套细胞淋巴瘤或滤泡性淋巴瘤所特有。目前报道的病例数量仍然太少，无法就这种重排的性质得出确凿结论。为了完善这一发现的临床和预后情况，需要更多病例的报道。
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