Schönfelder D, Stumm G, Bohle M, Niclas H J
Zentralinstitut für Organische Chemie, Akademie der Wissenschaften der DDR.
Pharmazie. 1988 Dec;43(12):837-9.
Studies on structure-activity relationships applied to quinoxaline 1,4-dioxides were performed on the basis of Hansch analysis. It could be demonstrated that correlations exist between MIC values (Escherichia coli) and physicochemical parameters. On the other hand, correlations were also found between nutritive effects determined on chicken and structural parameters. The results obtained could be confirmed by means of Free-Wilson analysis.
基于汉斯ch分析对喹喔啉1,4 -二氧化物的构效关系进行了研究。结果表明，最小抑菌浓度值（针对大肠杆菌）与物理化学参数之间存在相关性。另一方面，在鸡身上测定的营养效应与结构参数之间也发现了相关性。通过自由威尔逊分析可以证实所获得的结果。
