Faculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Qual Life Res. 2019 Jun;28(6):1531-1542. doi: 10.1007/s11136-019-02129-5. Epub 2019 Feb 7.
Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients.
132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations.
Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36-physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.
This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
慢性丙型肝炎（CHC）与健康相关生活质量（HRQOL）下降有关。最近的研究表明，患者报告的生活质量结果存在遗传基础。考虑到单核苷酸多态性（SNP）对 CHC 患者 HRQOL 的影响尚未得到研究，我们调查了 IL10-1082G/A、-819C/T 和-592C/A SNP 以及 IL6-174G/C SNP 的联合作用。我们还评估了人口统计学、临床、精神科、病毒学和遗传变量与 CHC 患者 HRQOL 各领域和综合评分之间的关联。
132 例连续 CHC 患者和 98 例对照者接受了迷你国际神经精神访谈（Mini International Neuropsychiatric Interview）的精神科评估。使用通用问卷、医疗结局研究 36 项简明健康调查（Medical Outcomes Study 36-Item Short Form Health Survey，SF-36）和特定的肝病生活质量问卷（Liver Disease Quality of Life Questionnaire，LDQOL）评估 HRQOL。通过 Taqman SNP 基因分型检测评估 IL6 和 IL10 多态性。采用多变量分析评估相关性。
重度抑郁症与 SF-36 和 LDQOL 的七个和十个领域的评分降低相关。糖尿病和高血压也与 HRQOL 降低相关。携带 IL10 ATA 单倍型/IL6-GG 基因型的 CHC 患者在 SF-36 生理功能领域的评分较低，在 LDQOL 中，肝脏疾病对日常生活活动、社会互动质量和性功能的影响的评分也较低，而非携带组合单倍型/基因型的患者。
这是第一项表明 IL6 高产生 GG 基因型和 IL10 低产生 ATA 单倍型与 CHC 患者 HRQOL 较差相关的研究。
