Kristiansson Stefan, Reizenstein Johan, von Beckerath Mathias, Landström Fredrik
a Department of Otolaryngology , Orebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital , Örebro , Sweden.
Acta Otolaryngol. 2019 Feb;139(2):195-200. doi: 10.1080/00016489.2018.1543950. Epub 2019 Feb 8.
Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field.
AIMS/OBJECTIVES: To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent.
Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration.
Five patients were cured by ECT as a mono-modality treatment after a median 10-year follow-up period. Two patients had recurrences and/or persisting tumors after treatment that required salvage surgery and radiotherapy. In two patients, the eye was spared with no visual impairment. In another patient, full facial nerve function was spared.
ECT can be a curative as well as an organ and function-sparing mono modality treatment in high-risk NMSC.
Today ECT is mostly used as a palliative treatment. Its curative potential should be further investigated. Randomized studies comparing ECT with standard treatment is needed. Hopefully, this small study can encourage such studies.
电化学疗法（ECT）是一种癌症治疗方式，通过施加电场增强化疗药物在细胞内的蓄积。
评估电化学疗法治疗具有治愈意图的高危非黑色素瘤皮肤癌（NMSC）后的长期疗效、安全性及功能结局。
对7例头颈部鳞状细胞癌（SCC）或基底细胞癌（BCC）患者采用电化学疗法并瘤内注射博来霉素进行治疗。
经过中位10年的随访期，5例患者通过电化学疗法单药治疗治愈。2例患者治疗后出现复发和/或肿瘤残留，需要补救性手术和放疗。2例患者的眼睛得以保留且无视力损害。另1例患者面神经功能完全保留。
在高危非黑色素瘤皮肤癌中，电化学疗法可以是一种治愈性的、保留器官及功能的单药治疗方法。
目前电化学疗法主要用作姑息治疗。其治愈潜力应进一步研究。需要开展将电化学疗法与标准治疗进行比较的随机研究。希望这项小型研究能够推动此类研究。
