Groselj Ales, Bosnjak Masa, Strojan Primoz, Krzan Mojca, Cemazar Maja, Sersa Gregor
Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Head Neck. 2018 Jan;40(1):120-125. doi: 10.1002/hed.24991. Epub 2017 Nov 11.
In the present study, effectiveness of electrochemotherapy was compared in patients with nonmelanoma skin cancer (NMSC) of the head and neck using standard and reduced doses of bleomycin.
Twenty-eight patients older than 65 years were prospectively treated with electrochemotherapy for nonmelanoma head and neck skin cancer. In the experimental group (n = 12 patients; 24 lesions), reduced bleomycin doses (10 000 IU/m ) were used. In the control group (n = 16 patients; 28 lesions), the standard bleomycin doses (15 000 IU/m ) were used. Tumor responses and side effects were monitored. These two groups were pair matched for the characteristics of patients (age, gender) and their tumors (diameter, histology type, recurrent lesions).
Complete tumor response at 2 months post-electrochemotherapy with the reduced bleomycin dose was 100% and with the standard bleomycin dose it was 96%. No statistically significant difference regarding skin toxicity was observed between the 2 groups (P = .20). Skin toxicity of grade 3 or less was recorded only in the control group (7% of treated lesions).
Presented results show the comparable antitumor effectiveness of electrochemotherapy when using standard or reduced bleomycin dose in elderly patients with nonmelanoma head and neck skin cancer.
在本研究中，比较了使用标准剂量和减少剂量博来霉素对头颈部非黑色素瘤皮肤癌（NMSC）患者进行电化学疗法的有效性。
对28例65岁以上的头颈部非黑色素瘤皮肤癌患者进行电化学疗法的前瞻性治疗。实验组（n = 12例患者；24个病灶）使用减少剂量的博来霉素（10000 IU/m²）。对照组（n = 16例患者；28个病灶）使用标准剂量的博来霉素（15000 IU/m²）。监测肿瘤反应和副作用。这两组在患者特征（年龄、性别）及其肿瘤特征（直径、组织学类型、复发病灶）方面进行配对匹配。
电化学疗法后2个月，使用减少剂量博来霉素时肿瘤完全缓解率为100%，使用标准剂量博来霉素时为96%。两组之间在皮肤毒性方面未观察到统计学显著差异（P = 0.20）。仅在对照组中记录到3级或以下的皮肤毒性（占治疗病灶的7%）。
研究结果表明，在老年头颈部非黑色素瘤皮肤癌患者中，使用标准剂量或减少剂量博来霉素进行电化学疗法时，抗肿瘤效果相当。
