Kumar Archana, Sridharn T B, Rao Kamini A
School of Biosciences and Technology, Vellore Institute of Technology University, Vellore, Tamil Nadu, India.
BACCMILANN Fertility Center Bangalore, Karnataka, India.
Protein Pept Lett. 2019;26(4):238-250. doi: 10.2174/0929866526666190208112152.
Seminal plasma proteins contributed by secretions of accessory glands plays a copious role in fertilization. Their role is overlooked for decades and even now, as Artificial Reproduction Techniques (ART) excludes the plasma components in the procedures. Recent evidences suggest the importance of these proteins starting from imparting fertility status to men, fertilization and till successful implantation of the conceptus in the female uterus. Seminal plasma is rich in diverse proteins, but a major part of the seminal plasma is constituted by very lesser number of proteins. This makes isolation and further research on non abundant protein a tough task. With the advent of much advanced proteomic techniques and bio informatics tools, studying the protein component of seminal plasma has become easy and promising. This review is focused on the role of seminal plasma proteins on various walks of fertilization process and thus, the possible exploitation of seminal plasma proteins for understanding the etiology of male related infertility issues. In addition, a compilation of seminal plasma proteins and their functions has been done.
附属腺分泌物产生的精浆蛋白在受精过程中发挥着重要作用。几十年来，它们的作用一直被忽视，即使在现在，人工生殖技术（ART）在操作过程中也排除了精浆成分。最近的证据表明，这些蛋白质的重要性体现在从赋予男性生育能力、受精到胚胎在女性子宫中成功着床的整个过程。精浆富含多种蛋白质，但其中很大一部分是由数量极少的蛋白质构成。这使得分离和进一步研究非丰富蛋白质成为一项艰巨的任务。随着先进得多蛋白质组学技术和生物信息学工具的出现，研究精浆的蛋白质成分变得容易且前景广阔。本综述聚焦于精浆蛋白在受精过程各个环节中的作用，以及因此可能利用精浆蛋白来理解男性相关不育问题的病因。此外，还对精浆蛋白及其功能进行了汇编。
