不育男性与正常男性群体精液质量与精液生化标志物：α-葡萄糖苷酶、果糖和锌之间的相关性

Correlation between semen quality and the seminal biochemical markers: alpha-glucosidase, fructose, and zinc in infertile men compared with a normal population of men.

作者信息

Rochdi Chaymae, Nasr Fahd A, Elrherabi Amal, Bellajdel Ibtissam, Taheri Hafsa, Bouhrim Mohamed, Al-Zharani Mohammed, Qurtam Ashraf Ahmed, Saadi Hanane, Mimouni Ahmed, Choukri Mohammed

机构信息

Maternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco.

Medically Assisted Procreation Unit, Central Laboratory, Mohammed VI University Hospital Center, Oujda, Morocco.

出版信息

Front Endocrinol (Lausanne). 2025 Aug 8;16:1583272. doi: 10.3389/fendo.2025.1583272. eCollection 2025.

DOI:10.3389/fendo.2025.1583272

PMID:40862122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12370449/

Abstract

INTRODUCTION

The male reproductive tract's accessory glands produce seminal biochemical markers that can help diagnose reproductive disorders and assess male fertility. This study evaluated the relationship between seminal biochemical components and sperm parameters in 150 men, including 20 normospermic individuals and 130 infertile patients classified into oligozoospermia, azoospermia, asthenozoospermia, teratozoospermia, and oligoasthenoteratozoospermia (OAT) groups.

METHODS

The patients underwent semen analysis and measurements of fructose, neutral alpha-glucosidase (NAG) and zinc in seminal plasma.

RESULTS AND DISCUSSIONS

The level of fructose was significantly decreased in asthenozoospermic and increased in oligoasthenoteratozoospermic (OAT) men. It was significantly correlated with semen volume, sperm concentration, progressive motility and morphology. Seminal neutral -glucosidase and zinc levels were found significantly reduced in azoospermic and OAT patients. The seminal NAG levels were significantly correlated with semen volume and progressive motility. For zinc level, the concentration was significantly correlated with sperm concentration (r = 0.041, p < 0.001).

摘要

引言

男性生殖道附属腺体会产生精液生化标志物，这些标志物有助于诊断生殖系统疾病并评估男性生育能力。本研究评估了150名男性精液生化成分与精子参数之间的关系，其中包括20名精子正常的个体以及130名不育患者，这些不育患者被分为少精子症、无精子症、弱精子症、畸形精子症和少弱畸精子症（OAT）组。

方法

患者接受了精液分析以及精浆中果糖、中性α-葡萄糖苷酶（NAG）和锌含量的测定。

结果与讨论

弱精子症患者的果糖水平显著降低，而少弱畸精子症（OAT）男性的果糖水平升高。果糖水平与精液量、精子浓度、前向运动能力和形态显著相关。无精子症和少弱畸精子症（OAT）患者的精浆中性葡萄糖苷酶和锌水平显著降低。精浆NAG水平与精液量和前向运动能力显著相关。就锌水平而言，其浓度与精子浓度显著相关（r = 0.041，p < 0.001）。