镍催化的芳基卤化物和杂芳基卤化物的电化学硫醇化反应
Nickel-Catalyzed Thiolation of Aryl Halides and Heteroaryl Halides through Electrochemistry.
作者信息
Liu Dong, Ma Hong-Xing, Fang Ping, Mei Tian-Sheng
机构信息
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai, 200032, China.
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, China.
出版信息
Angew Chem Int Ed Engl. 2019 Apr 1;58(15):5033-5037. doi: 10.1002/anie.201900956. Epub 2019 Mar 6.
Transition-metal-catalyzed coupling reactions are useful tools for synthesizing aryl sulfur compounds. However, conventional transition-metal-catalyzed thiolation of aryl bromides and chlorides typically requires the use of strong base under elevated reaction temperature. Herein, we report the first examples of nickel-catalyzed electrochemical thiolation of aryl bromides and chlorides in the absence of an external base at room temperature using undivided electrochemical cells.
过渡金属催化的偶联反应是合成芳基硫化合物的有用工具。然而，传统的过渡金属催化的芳基溴化物和氯化物的硫醇化反应通常需要在升高的反应温度下使用强碱。在此，我们报道了首例在室温下使用未分隔的电化学电池，在无外部碱的情况下镍催化芳基溴化物和氯化物的电化学硫醇化反应。
Zotero 插件