Zeng Huiying, Dou Qian, Li Chao-Jun
The State Key Laboratory of Applied Organic Chemistry , Lanzhou University , 222 Tianshui Road , Lanzhou 730000 , People's Republic of China.
Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada.
Org Lett. 2019 Mar 1;21(5):1301-1305. doi: 10.1021/acs.orglett.8b04081. Epub 2019 Feb 8.
Photoinduced transition-metal- and photosensitizer-free cross-coupling of aryl halides (including Ar-Cl, Ar-Br, and Ar-I) with H-phosphonates (including dialkyl phosphonates and diarylphosphine oxides) is reported. Various functional groups were tolerated, including ester, methoxy, dimethoxy, alkyl, phenyl, trifluoromethyl, and heterocyclic compounds. This simple and green strategy provides a practical pathway to synthesize arylphosphine oxides.
报道了芳基卤化物（包括芳基氯、芳基溴和芳基碘）与H-膦酸酯（包括二烷基膦酸酯和二芳基氧化膦）的光诱导无过渡金属和无光敏剂的交叉偶联反应。该反应能耐受多种官能团，包括酯基、甲氧基、二甲氧基、烷基、苯基、三氟甲基和杂环化合物。这种简单且绿色的策略为合成芳基氧化膦提供了一条实用途径。
