囊杆菌素920-1和920-2：通过全合成确定其结构与相对构型
Cystobactamids 920-1 and 920-2: Assignment of the Constitution and Relative Configuration by Total Synthesis.
作者信息
Planke Therese, Moreno María, Hüttel Stephan, Fohrer Jörg, Gille Franziska, Norris Matthew D, Siebke Maik, Wang Liangliang, Müller Rolf, Kirschning Andreas
机构信息
Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ) der Leibniz Universität Hannover , Schneiderberg 1B , 30167 Hannover , Germany.
Abteilung Mikrobielle Naturstoffe , Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung und Universität des Saarlandes , Campus E8.1 , 66123 Saarbrücken , Germany.
出版信息
Org Lett. 2019 Mar 1;21(5):1359-1363. doi: 10.1021/acs.orglett.9b00058. Epub 2019 Feb 8.
Total synthesis of cystobactamid 920-1 and its epimer has allowed an unambiguous assignment of the relative and absolute configuration of the natural product. A careful structural analysis of each isomer using both NMR and computational techniques also prompted a constitutional revision of the structures originally reported for cystobactamids 920-1 and 920-2, and has provided further insight into the unique conformational preferences of the cystobactamid family.
胱硫醚酰胺920-1及其差向异构体的全合成使得能够明确确定该天然产物的相对构型和绝对构型。使用核磁共振（NMR）和计算技术对每种异构体进行仔细的结构分析，也促使对最初报道的胱硫醚酰胺920-1和920-2的结构进行了结构修正，并进一步深入了解了胱硫醚酰胺家族独特的构象偏好。
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