Higashi Yusuke, Gautam Sandeep, Delafontaine Patrick, Sukhanov Sergiy
Department of Medicine, School of Medicine, University of Missouri, Columbia, MO, United States; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States.
Department of Medicine, School of Medicine, University of Missouri, Columbia, MO, United States.
Growth Horm IGF Res. 2019 Apr;45:6-16. doi: 10.1016/j.ghir.2019.01.002. Epub 2019 Jan 31.
Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke, and peripheral arterial disease. Atherosclerosis is a multifactorial disorder and its pathophysiology is highly complex. Changes in expression of multiple genes coupled with environmental and lifestyle factors initiate cascades of adverse events involving multiple types of cells (e.g. vascular endothelial cells, smooth muscle cells, and macrophages). IGF-1 is a pleiotropic factor, which is found in the circulation (endocrine IGF-1) and is also produced locally in arteries (endothelial cells and smooth muscle cells). IGF-1 exerts a variety of effects on these cell types in the context of the pathogenesis of atherosclerosis. In fact, there is an increasing body of evidence suggesting that IGF-1 has beneficial effects on the biology of atherosclerosis. This review will discuss recent findings relating to clinical investigations on the relation between IGF-1 and cardiovascular disease and basic research using animal models of atherosclerosis that have elucidated some of the mechanisms underlying atheroprotective effects of IGF-1.
动脉粥样硬化是一种炎症性动脉致病状态，可导致缺血性心血管疾病，如冠状动脉疾病、心肌梗死、中风和外周动脉疾病。动脉粥样硬化是一种多因素疾病，其病理生理学高度复杂。多种基因表达的变化以及环境和生活方式因素引发了涉及多种类型细胞（如血管内皮细胞、平滑肌细胞和巨噬细胞）的一系列不良事件。胰岛素样生长因子-1（IGF-1）是一种多效性因子，存在于循环中（内分泌IGF-1），也在动脉局部（内皮细胞和平滑肌细胞）产生。在动脉粥样硬化的发病机制中，IGF-1对这些细胞类型发挥多种作用。事实上，越来越多的证据表明IGF-1对动脉粥样硬化生物学具有有益作用。本综述将讨论近期有关IGF-1与心血管疾病关系的临床研究以及使用动脉粥样硬化动物模型的基础研究的相关发现，这些研究阐明了IGF-1抗动脉粥样硬化作用的一些潜在机制。
