Janssen J A, Stolk R P, Pols H A, Grobbee D E, Lamberts S W
Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands.
Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):277-82. doi: 10.1161/01.atv.18.2.277.
Recently, a method to measure free insulin-like growth factor-I (IGF-I) levels has been developed. Free IGF-I levels may have greater physiological and clinical relevance than total (bound and free) IGF-I. The associations between the circulating IGF-I/IGF binding protein (IGFBP) system and cardiovascular disorders was studied. In a cross-sectional study of 218 healthy persons (103 men, 115 women) aged 55 to 80 years, fasting serum (total and free) IGF-I and IGFBP-1 levels, lipid profile, insulin, and glucose were measured. In addition, blood pressure, body mass index (BMI), and waist-hip ratio (WHR) were measured. Ultrasonography of both carotid arteries was performed to investigate the presence of atherosclerotic lesions. A history of angina pectoris, the presence of a possible or definite myocardial infarction on the ECG, and plaques in the carotid arteries were used as indicators of presence of cardiovascular signs and symptoms. Free IGF-I was inversely related to serum triglycerides (P=.04, adjusted for age and sex). Mean free IGF-I levels in subjects without signs or symptoms of cardiovascular diseases were significantly higher than in those with at least one cardiovascular symptom or sign (P=.002, adjusted for age and sex). Free IGF-I levels were also higher in subjects who had no atherosclerotic plaques in the carotid arteries (P=.02, adjusted for age and sex) and who had never smoked (P=.02, adjusted for age and sex). IGFBP-1 showed an inverse relation with insulin, BMI, and WHR and a positive relation with HDL cholesterol. The associations between IGFBP-1 levels and HDL cholesterol, WHR, and BMI remained significant after adjustment for fasting insulin levels. High fasting serum free IGF-I levels are associated with a decreased presence of atherosclerotic plaques and coronary artery disease and lower serum triglycerides, whereas high fasting IGFBP-1 levels are associated with a more favorable cardiovascular risk profile. The findings suggest that the IGF-I/IGFBP system is related to cardiovascular risk factors and atherosclerosis.
最近，一种测量游离胰岛素样生长因子-I（IGF-I）水平的方法已被开发出来。游离IGF-I水平可能比总（结合和游离）IGF-I具有更大的生理和临床相关性。对循环IGF-I/IGF结合蛋白（IGFBP）系统与心血管疾病之间的关联进行了研究。在一项对218名年龄在55至80岁的健康人（103名男性，115名女性）的横断面研究中，测量了空腹血清（总IGF-I和游离IGF-I）和IGFBP-1水平、血脂谱、胰岛素和血糖。此外，还测量了血压、体重指数（BMI）和腰臀比（WHR）。对双侧颈动脉进行超声检查以调查动脉粥样硬化病变的存在情况。心绞痛病史、心电图上可能或确定的心肌梗死的存在以及颈动脉斑块被用作心血管体征和症状存在的指标。游离IGF-I与血清甘油三酯呈负相关（P = 0.04，经年龄和性别校正）。无心血管疾病体征或症状的受试者的平均游离IGF-I水平显著高于至少有一项心血管症状或体征的受试者（P = 0.002，经年龄和性别校正）。在颈动脉中没有动脉粥样硬化斑块的受试者（P = 0.02，经年龄和性别校正）以及从不吸烟的受试者（P = 0.02，经年龄和性别校正）中，游离IGF-I水平也较高。IGFBP-1与胰岛素、BMI和WHR呈负相关，与高密度脂蛋白胆固醇呈正相关。在调整空腹胰岛素水平后，IGFBP-1水平与高密度脂蛋白胆固醇、WHR和BMI之间的关联仍然显著。空腹血清游离IGF-I水平高与动脉粥样硬化斑块和冠状动脉疾病的存在减少以及血清甘油三酯降低有关，而空腹IGFBP-1水平高与更有利的心血管风险状况有关。研究结果表明，IGF-I/IGFBP系统与心血管危险因素和动脉粥样硬化有关。
