雌激素与认知功能。

Estrogen and cognitive functions.

作者信息

Gasbarri Antonella, Pompili Assunta, Clotilde Tavares Maria, Tomaz Carlos

机构信息

a Department of Biomedical Sciences and Technologies, Faculty of Sciences of Education, University of L'Aquila, via Vetoio, 67100 L'Aquila, Italy.

b Department of Biomedical Sciences and Technologies, Faculty of Sciences of Education, University of L'Aquila, via Vetoio, 67100 L'Aquila, Italy.

出版信息

Expert Rev Endocrinol Metab. 2009 Sep;4(5):507-520. doi: 10.1586/eem.09.30.

DOI:10.1586/eem.09.30

PMID:30736189

Abstract

Although the effects of estrogen on sexual behavior in mammals are well known, its role on other types of behavior, including cognition, have only recently been recognized. This review summarizes work conducted in our laboratory and others with the aim of identifying the effects of estrogen on cognitive functions. The first section will briefly describe the neurobiology of estrogen. The second section will discuss the effects of estrogen on cognitive behaviors in mammals, as well as the physiological relevance of these effects and their applicability to human health and disease. The third section will detail the role of estrogen on working memory in humans and nonhuman primates, and in rodents. Finally, the concluding section will briefly describe the relationship between estrogen and the aging brain.

摘要

虽然雌激素对哺乳动物性行为的影响已广为人知，但其对包括认知在内的其他行为类型的作用直到最近才被认识到。本综述总结了我们实验室及其他机构开展的研究工作，旨在确定雌激素对认知功能的影响。第一部分将简要描述雌激素的神经生物学。第二部分将讨论雌激素对哺乳动物认知行为的影响，以及这些影响的生理相关性及其在人类健康和疾病中的适用性。第三部分将详细阐述雌激素在人类、非人灵长类动物和啮齿动物工作记忆中的作用。最后，结论部分将简要描述雌激素与衰老大脑之间的关系。