Rovira-Llopis Susana, Hernández-Mijares Antonio, Rocha Milagros, Victor Victor M
a Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), University Hospital Doctor Peset, Avda Gaspar Aguilar 90, 46017, Valencia, Spain.
b Service of Endocrinology, University Hospital Doctor Peset, Valencia, Spain.
Expert Rev Endocrinol Metab. 2014 Nov;9(6):629-639. doi: 10.1586/17446651.2014.949242. Epub 2014 Aug 14.
Obesity is a major risk factor for multiple severe health conditions, including cardiovascular diseases, diabetes and cancer. It is often related to an increased risk of morbidity and mortality and, as it can be accompanied by non-fatal health problems, quality of life is seriously reduced due to related conditions including hypertension, sleep apnea, osteoarthritis, respiratory problems and infertility. Evidence suggests that oxidative stress is related to obesity and its complications. In obese patients, there is an increase in levels of reactive oxygen species and nitrogen species and antioxidant defenses are undermined in comparison to normal-weight counterparts. In addition, these parameters inversely correlate with central adiposity. In this review, the authors discuss current concepts concerning the relationship between obesity and oxidative stress and mitochondrial impairment. Potential interventions to improve redox balance are also explored.
肥胖是多种严重健康状况的主要风险因素，包括心血管疾病、糖尿病和癌症。它通常与发病和死亡风险增加有关，而且由于可能伴有非致命性健康问题，包括高血压、睡眠呼吸暂停、骨关节炎、呼吸问题和不孕症等相关状况会严重降低生活质量。有证据表明，氧化应激与肥胖及其并发症有关。在肥胖患者中，活性氧和氮物种水平升高，与正常体重者相比，抗氧化防御能力受到损害。此外，这些参数与中心性肥胖呈负相关。在这篇综述中，作者讨论了关于肥胖与氧化应激及线粒体损伤之间关系的当前概念。还探讨了改善氧化还原平衡的潜在干预措施。
