Centre for Sleep and Chronobiology (CIRUS), Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia.
Uppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden.
J Clin Sleep Med. 2019 Feb 15;15(2):201-206. doi: 10.5664/jcsm.7616.
The aim of this study was to determine whether severity measures of obstructive sleep apnea (OSA) are associated with arterial stiffness and central blood pressure (two important cardiovascular risk factors) in a large group of patients with OSA.
Baseline data from six studies on OSA in which arterial stiffness and central aortic blood pressure measures were determined using applanation tonometry were pooled. Associations between measures of arterial stiffness (heart rate corrected augmentation index [AI75]), central aortic blood pressure (central systolic pressure [CSP] and heart rate corrected central augmentation pressure [CAP75]) and measures of OSA severity were explored using stepwise regression modelling.
Data from 362 participants (M:F ratio 13:1) with mean (standard deviation) age 49.2 (11.0) years, body mass index 31.9 (5.3) kg/m, apnea-hypopnea index (AHI) 35.7 (20.7) events/h were included in the analyses. The AHI, oxygen desaturation index (ODI3%), and sleep time with SpO < 90% (T90) were all associated with arterial stiffness (AI75), (AHI: adj. β = .069; = .01; ODI3%: adj. β = .072; = .01; T90: adj. β = .18; < .0001) and CAP75 (AHI: adj. β = .030; = .01; ODI3%: adj. β = .027; = .02; T90: adj. β = .080; < .0001). AHI was also associated with CSP (AHI: adj. β = .11; = .002).
OSA severity was significantly associated with augmentation index and CAP75 although the relationships were not strong.
本研究旨在确定阻塞性睡眠呼吸暂停（OSA）严重程度指标与大样本 OSA 患者的动脉僵硬度和中心动脉血压（两个重要的心血管危险因素）之间的关系。
汇总了六项使用平板张力测定法测定动脉僵硬度和中心主动脉血压的 OSA 研究的基线数据。使用逐步回归模型探讨了动脉僵硬度指标（心率校正增强指数[AI75]）、中心主动脉血压指标（中心收缩压[CSP]和心率校正中心增强压[CAP75]）与 OSA 严重程度指标之间的相关性。
共纳入 362 名参与者（男女比例 13:1）的数据，平均（标准差）年龄 49.2（11.0）岁，体重指数 31.9（5.3）kg/m2，呼吸暂停低通气指数（AHI）为 35.7（20.7）事件/小时。AHI、氧减饱和度指数（ODI3%）和 SpO<90%（T90）睡眠时间与动脉僵硬度（AI75）和 CAP75 均相关（AHI：调整后β=0.069；P=0.01；ODI3%：调整后β=0.072；P=0.01；T90：调整后β=0.18；P<0.0001）。AHI 还与 CSP 相关（AHI：调整后β=0.11；P=0.002）。
尽管相关性不强，但 OSA 严重程度与增强指数和 CAP75 显著相关。
