Zdravkovic Marija, Popadic Viseslav, Klasnja Slobodan, Milic Natasa, Rajovic Nina, Divac Anica, Manojlovic Andrea, Nikolic Novica, Lukic Filip, Rasiti Esma, Mircetic Katarina, Marinkovic Djordje, Nikolic Sofija, Crnokrak Bogdan, Lisulov Danica Popovic, Djurasevic Sinisa, Stojkovic Maja, Todorovic Zoran, Lasica Ratko, Parapid Biljana, Djuran Predrag, Brajkovic Milica
University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Front Pharmacol. 2022 Jun 15;13:898072. doi: 10.3389/fphar.2022.898072. eCollection 2022.
The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). The study was conducted as a prospective cohort study including 120 patients with newly diagnosed OSA between 2019 and 2020, at University Clinical Hospital Center "Bezanijska kosa", Belgrade, Serbia. The diagnosis was established by polysomnography. In all patients, sociodemographic data, respiratory, lipid, and inflammatory parameters were collected and complete echocardiographic study and 24-h blood pressure monitoring were performed. The mean patient age was 55.7 ± 13.8 years. Study population was mostly male (70.0%) and obese (56.7%). At least 30 apneas or hypopneas per hour were present in 39.0% of patients. A strong positive correlation was found between OSA severity and BMI (r = 0.562, < 0.001), both associated with lipid, inflammatory and respiratory parameters, and cardiovascular profile of patients with OSA ( < 0.05 for all). Echocardiographic study and 24-h blood pressure monitoring parameters were in turn correlated with lipid and inflammatory markers ( < 0.05 for all). The results of this study support the important role of dyslipidemia and inflammation, as well as coexistence of obesity in the pathogenesis of numerous conditions linked with an increased risk of cardiovascular morbidity and mortality in patients with OSA.
本研究旨在确定脂质异常和炎症标志物在心血管风险发展中的作用，并探讨肥胖作为阻塞性睡眠呼吸暂停（OSA）患者常见合并症的重要性。该研究作为一项前瞻性队列研究进行，纳入了2019年至2020年间在塞尔维亚贝尔格莱德“贝扎尼什卡科萨”大学临床中心新诊断为OSA的120例患者。诊断通过多导睡眠图确定。收集了所有患者的社会人口统计学数据、呼吸、脂质和炎症参数，并进行了完整的超声心动图研究和24小时血压监测。患者的平均年龄为55.
