萎缩性舌炎患者的胃壁细胞和甲状腺自身抗体。
Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.
机构信息
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
J Formos Med Assoc. 2019 Jun;118(6):973-978. doi: 10.1016/j.jfma.2019.01.016. Epub 2019 Feb 5.
BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.
METHODS
Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects.
RESULTS
We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively.
CONCLUSION
Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.
背景/目的：胃壁细胞抗体（GPCA）、甲状腺球蛋白抗体（TGA）和甲状腺微粒体抗体（TMA）是器官特异性自身抗体。本研究主要评估萎缩性舌炎（AG）患者血清 GPCA、TGA 和 TMA 存在的频率。
方法
测量了 1064 例 AG 患者和 532 名年龄和性别匹配的健康对照者的血清 GPCA、TGA 和 TMA 水平。
结果
我们发现，1064 例 AG 患者中分别有 26.7%、28.4%和 29.8%和 532 例健康对照者中分别有 2.3%、2.1%和 2.6%的血清 GPCA、TGA 和 TMA 阳性。AG 患者的 GPCA、TGA 或 TMA 阳性频率明显高于健康对照组（所有 P 值均<0.001）。我们还发现，67（6.3%）、181（17.0%）和 340（32.0%）例 AG 患者和 3（0.6%）、10（1.9%）和 8（1.5%）例健康对照者的血清中存在三种（GPCA+TGA+TMA）、两种（GPCA+TGA、GPCA+TMA 或 TGA+TMA）或一种（仅 GPCA、仅 TGA 或仅 TMA）器官特异性自身抗体。在 373 例 TGA/TMA 阳性的 AG 患者中，其血清促甲状腺激素（TSH）水平可测量，其中 78.6%、8.0%和 13.4%的 TGA/TMA 阳性 AG 患者的血清 TSH 水平分别为正常、较低和较高。
结论
约 55.3%的 1064 例 AG 患者血清 GPCA/TGA/TMA 阳性。由于部分 GPCA 阳性的 AG 患者可能发展为恶性贫血、自身免疫性萎缩性胃炎和胃癌，部分 TGA/TMA 阳性的 AG 患者可能出现甲状腺功能亢进和甲状腺功能减退等甲状腺功能障碍，这些自身抗体阳性的 AG 患者应转介给医生进行进一步治疗。
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