灼口综合征患者的胃壁细胞和甲状腺自身抗体。
Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome.
机构信息
Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.
出版信息
J Formos Med Assoc. 2020 Dec;119(12):1758-1763. doi: 10.1016/j.jfma.2020.08.035. Epub 2020 Sep 1.
BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients.
METHODS
Serum GPCA, TGA, and TMA levels were measured in 884 BMS patients and in 442 age- and sex-matched healthy control subjects.
RESULTS
We found that 12.3%, 21.6%, and 22.7% of 884 BMS patients and 1.8%, 2.3%, and 2.9% of 442 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. BMS patients had significantly higher frequencies of GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). We also found that 20 (2.3%), 130 (14.7%), and 181 (20.5%) BMS patients and 3 (0.7%), 8 (1.8%), and 6 (1.4%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 255 TGA/TMA-positive BMS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.8%, 5.1%, and 7.1% of these TGA/TMA-positive BMS patients had normal, lower, and higher serum TSH levels, respectively.
CONCLUSION
Approximately 37.5% of 884 BMS patients have serum GPCA/TGA/TMA positivity. Moreover, 12.3%, 21.6%, and 22.7% of 884 BMS patients have the serum GPCA, TGA, and TMA positivities, respectively. Only 5.1% and 7.1% of TGA/TMA-positive BMS patients have hyperthyroidism and hypothyroidism, respectively. It needs further studies to know whether GPCA-positive BMS patients may finally become as having autoimmune atrophic gastritis.
背景/目的：胃壁细胞抗体（GPCA）、甲状腺球蛋白抗体（TGA）和甲状腺微粒体抗体（TMA）是器官特异性自身抗体。本研究主要评估了口腔灼口综合征（BMS）患者血清 GPCA、TGA 和 TMA 阳性率。
方法
检测了 884 例 BMS 患者和 442 名年龄和性别匹配的健康对照者血清 GPCA、TGA 和 TMA 水平。
结果
我们发现，884 例 BMS 患者中分别有 12.3%、21.6%和 22.7%、442 例健康对照者中分别有 1.8%、2.3%和 2.9%血清 GPCA、TGA 和 TMA 阳性。BMS 患者 GPCA、TGA 和 TMA 阳性率显著高于健康对照组（均 P 值<0.001）。我们还发现，20 例（2.3%）、130 例（14.7%）和 181 例（20.5%）BMS 患者和 3 例（0.7%）、8 例（1.8%）和 6 例（1.4%）健康对照者血清中存在三种（GPCA+TGA+TMA）、两种（GPCA+TGA、GPCA+TMA 或 TGA+TMA）或一种（仅 GPCA、仅 TGA 或仅 TMA）器官特异性自身抗体。在 255 例 TGA/TMA 阳性的 BMS 患者中，有 87.8%、5.1%和 7.1%的患者血清 TSH 水平正常、较低和较高。
结论
约 37.5%的 884 例 BMS 患者血清 GPCA/TGA/TMA 阳性。此外，884 例 BMS 患者中分别有 12.3%、21.6%和 22.7%血清 GPCA、TGA 和 TMA 阳性。仅有 5.1%和 7.1%的 TGA/TMA 阳性 BMS 患者患有甲状腺功能亢进症和甲状腺功能减退症。需要进一步研究以确定 GPCA 阳性的 BMS 患者是否最终会发生自身免疫性萎缩性胃炎。
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