萎缩性舌炎患者的血液特征，这些患者的甲状腺球蛋白抗体/甲状腺微粒体抗体阳性，但胃壁细胞抗体阴性。
Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity.
机构信息
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
J Formos Med Assoc. 2019 Aug;118(8):1218-1224. doi: 10.1016/j.jfma.2019.04.002. Epub 2019 Apr 17.
BACKGROUND/PURPOSE: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA/TMAAG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA/TMAAG patients.
METHODS
The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA/TMAAG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects.
RESULTS
We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA/TMAAG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA/TMAAG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA/TMAAG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients.
CONCLUSION
The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA/TMAAG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA/TMAAG patients.
背景/目的：我们之前的研究发现，在 1064 例萎缩性舌炎（AG）患者中，有 304 例患者甲状腺球蛋白抗体（TGA）和/或甲状腺微粒体抗体（TMA）阳性，但胃壁细胞抗体（GPCA）阴性，即 TGA/TMA+GPCA-患者。本研究主要评估 TGA/TMA 阳性在 TGA/TMA+GPCA-患者中是否与贫血、血液营养缺乏和高同型半胱氨酸血症显著相关。
方法
测量并比较了 304 例 TGA/TMA+GPCA-AG 患者与 476 例 GPCA 阴性、TGA 阴性和 TMA 阴性 AG 患者（TGA/TMA+GPCA-AG 患者）或 532 例健康对照组之间的平均血血红蛋白（Hb）、铁、维生素 B12、叶酸和同型半胱氨酸水平。
结果
与 532 例健康对照组相比，我们发现 304 例 TGA/TMA+GPCA-AG 患者的 MCV 显著降低，平均血 Hb 和铁水平显著降低，小细胞、大细胞、血 Hb、铁、维生素 B12 和叶酸缺乏以及高同型半胱氨酸血症的发生率显著增加。然而，我们没有发现 304 例 TGA/TMA+GPCA-AG 患者与 476 例 TGA/TMA+GPCA-AG 患者之间的 MCV 和平均血 Hb、铁、维生素 B12、叶酸和同型半胱氨酸水平以及小细胞、大细胞、血 Hb、铁和叶酸缺乏以及高同型半胱氨酸血症的发生率存在显著差异。TGA/TMA+GPCA-AG 患者的血清维生素 B12 缺乏发生率显著高于 TGA/TMA+GPCA-AG 患者。
结论
AG 本身的疾病在 TGA/TMA+GPCA-AG 患者中导致贫血、血液营养缺乏和高同型半胱氨酸血症方面起着重要作用。然而，TGA/TMA 阳性与 TGA/TMA+GPCA-AG 患者的贫血、血清铁和叶酸缺乏以及高同型半胱氨酸血症并无显著相关性。
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