Section of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago Medicine, Chicago, IL.
Section of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago Medicine, Chicago, IL.
J Am Med Dir Assoc. 2019 Jun;20(6):672-678. doi: 10.1016/j.jamda.2018.12.002. Epub 2019 Feb 6.
Aging researchers have been studying frailty for decades. Experts agree that frailty is a medical syndrome marked by reduced physiologic function, which increases the risk of vulnerability and short-term mortality, particularly in the face of a stressor. Frailty has been shown to predict poor outcomes including falls, disability, major morbidity following surgery, and mortality among older adults. Despite hundreds of papers identifying frailty as a useful marker of risk, its translation into clinical practice has lagged. The Successful Aging and Frailty Evaluation (SAFE) clinic was established in 2011 specifically to implement routine and structured frailty assessment and management in a variety of referred patients. Now, more than 7 years after its inception, we offer our "in the trenches" clinical perspective on logistical challenges, the clinical utility of the frailty assessment, and future frailty needs and targets to help further the frailty translation research efforts.
衰老研究人员研究虚弱状态已经数十年了。专家们一致认为，虚弱是一种医学综合征，其特征是生理功能下降，这会增加脆弱性和短期死亡率的风险，尤其是在面临压力源时。虚弱状态已被证明可预测不良结局，包括跌倒、残疾、手术后出现重大发病率和老年人的死亡率。尽管有数百篇论文将虚弱状态确定为有用的风险标志物，但将其转化为临床实践却一直滞后。成功老龄化和虚弱评估（SAFE）诊所成立于 2011 年，专门在各种转介患者中实施常规和结构化的虚弱评估和管理。现在，从成立到现在已经过去了 7 年多，我们提供了关于后勤挑战、虚弱评估的临床实用性以及未来虚弱需求和目标的“实战”临床观点，以帮助进一步推动虚弱状态的转化研究工作。
