组蛋白去乙酰化酶 HDA19 通过与 SCARECROW 相互作用影响根皮层细胞命运。
Histone Deacetylase HDA19 Affects Root Cortical Cell Fate by Interacting with SCARECROW.
机构信息
State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.
Department of Biology and Howard Hughes Medical Institute, Duke University, Durham, North Carolina 27708.
出版信息
Plant Physiol. 2019 May;180(1):276-288. doi: 10.1104/pp.19.00056. Epub 2019 Feb 8.
Abstract
The Arabidopsis () root epidermis is a simple model for investigating cell fate specification and pattern formation. In addition to regulatory networks consisting of transcription factors, histone deacetylases are also involved in the formation of cellular patterns. Here, we report thatHistone Deacetylase19 (HDA19) affects the root epidermal cellular pattern through regulation of cortical cell fate by interacting with SCARECROW (SCR). HDA19 binds to the DNA sequence upstream of , as well as to those of several of SCR's target genes, and regulates their expression. Mutant lines of several SCR target genes show impaired patterns of epidermal differentiation and cortical cell division, similar to that of This work presents HDA19 and SCR as two further players in the regulation of cortical and epidermal cell specification and describes an additional function for SCR.
摘要
拟南芥的根表皮是研究细胞命运特化和模式形成的简单模型。除了由转录因子组成的调控网络外，组蛋白去乙酰化酶也参与了细胞模式的形成。在这里，我们报道Histone Deacetylase19 (HDA19) 通过与 SCARECROW (SCR) 相互作用来调节皮层细胞命运，从而影响根表皮细胞的模式。HDA19 与 的上游 DNA 序列以及 SCR 的几个靶基因的上游 DNA 序列结合，并调节它们的表达。几个 SCR 靶基因的突变系显示出表皮分化和皮层细胞分裂模式受损，类似于 的情况。这项工作将 HDA19 和 SCR 作为皮层和表皮细胞特化调控的另外两个因子，并描述了 SCR 的一个额外功能。
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