Institute of Pharmacology, University of Bern, Bern, Switzerland.
Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia.
Cell Death Differ. 2019 Mar;26(4):715-727. doi: 10.1038/s41418-019-0297-6. Epub 2019 Feb 8.
Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes and to carry out their clearance by dismemberment in the course of catabolic processes in the lysosome. Clearly, this is a non-metabolic function of autophagy that impacts strongly on the immune system. While in a preceding article on neutrophils, eosinophils, mast cells, and natural killer cells our focus was on the role of autophagy in regulating innate immune cell differentiation, degranulation, phagocytosis and extracellular trap formation, here we discuss monocytes/macrophages and dendritic cells, specifically, the influence of autophagy on functional cellular responses, such as phagocytosis, antigen presentation, cytokine production, control of inflammasome activation, tolerance and the consequences for overall host defense.
自噬在功能上能够很好地将微生物病原体隔离在自噬体中，并在溶酶体的分解代谢过程中通过解体来清除它们。显然，这是自噬的一种非代谢功能，它对免疫系统有很大的影响。在前一篇关于中性粒细胞、嗜酸性粒细胞、肥大细胞和自然杀伤细胞的文章中，我们关注的是自噬在调节先天免疫细胞分化、脱粒、吞噬和细胞外陷阱形成中的作用，在这里，我们讨论单核细胞/巨噬细胞和树突状细胞，特别是自噬对吞噬作用、抗原呈递、细胞因子产生、控制炎症小体激活、耐受和对宿主防御的整体影响等功能细胞反应的影响。
