自噬对固有免疫系统的调节：中性粒细胞、嗜酸性粒细胞、肥大细胞、自然杀伤细胞。
Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells.
机构信息
Institute of Pharmacology, University of Bern, Bern, Switzerland.
Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia.
出版信息
Cell Death Differ. 2019 Mar;26(4):703-714. doi: 10.1038/s41418-019-0295-8. Epub 2019 Feb 8.
Abstract
Autophagy is an evolutionally conserved, highly regulated catabolic process that combines cellular functions required for the regulation of metabolic balance under conditions of stress with those needed for the degradation of damaged cell organelles via the lysosomal machinery. The importance of autophagy for cell homeostasis and survival has long been appreciated. Recent data suggest that autophagy is also involved in non-metabolic functions that impact the immune system. Here, we reflect in two review articles the recent literature pointing to an important role for autophagy in innate immune cells. In this article, we focus on neutrophils, eosinophils, mast cells, and natural killer cells. We mainly discuss the influence of autophagy on functional cellular responses and its importance for overall host defense. In the companion review, we present the role of autophagy in the functions performed by monocytes/macrophages and dendritic cells.
摘要
自噬是一种进化上保守的、高度调控的分解代谢过程，它将细胞功能结合起来，这些功能在应激条件下调节代谢平衡，同时也需要通过溶酶体机制降解受损的细胞器。自噬对于细胞的内稳态和生存的重要性早已被人们所认识。最近的数据表明，自噬也参与了非代谢功能，这些功能影响免疫系统。在这里，我们在两篇综述文章中反映了最近的文献，这些文献指出自噬在天然免疫细胞中起着重要作用。在本文中，我们重点关注中性粒细胞、嗜酸性粒细胞、肥大细胞和自然杀伤细胞。我们主要讨论了自噬对功能性细胞反应的影响及其对宿主整体防御的重要性。在相关综述中，我们介绍了自噬在单核细胞/巨噬细胞和树突状细胞功能中的作用。
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本文引用的文献
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Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation.自噬对固有免疫系统的调控：单核细胞、巨噬细胞、树突状细胞和抗原呈递。
Cell Death Differ. 2019 Mar;26(4):715-727. doi: 10.1038/s41418-019-0297-6. Epub 2019 Feb 8.
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Untangling "NETosis" from NETs.从 NETs 中解开“NETosis”。
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Exploring the Role of Autophagy-Related Gene 5 () Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases.探讨自噬相关基因 5() 在自身免疫/自身炎症性疾病中的自噬作用
Front Immunol. 2018 Oct 17;9:2334. doi: 10.3389/fimmu.2018.02334. eCollection 2018.
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