对胰腺癌肿瘤基质耗竭的思考。
Reflections on depletion of tumor stroma in pancreatic cancer.
机构信息
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China.
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China.
出版信息
Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):267-272. doi: 10.1016/j.bbcan.2019.01.007. Epub 2019 Feb 6.
Pancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role of the stroma in cancer metastasis may improve therapeutic approaches by allowing them to harness specific features of the stroma to treat pancreatic cancer.
胰腺癌的特征是具有极其密集的基质，这通过为治疗剂创建物理和生物屏障来促进化学抗性。因此，基质耗竭剂可以增强化疗药物的递送和疗效。然而，针对胰腺癌的基质靶向治疗是一把双刃剑，因为基质也可以抑制肿瘤转移和恶性程度。深入了解基质在癌症转移中的关键作用可以通过允许它们利用基质的特定特征来治疗胰腺癌，从而改善治疗方法。
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