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A 90-day subchronic toxicology screen of genetically modified rice Lac-3 and its effects on the gut microbiota in Sprague-Dawley rats.
机构信息
College of Food Science and Nutritional Engineering, China Agricultural University, No.17 Qinghua East Road, Beijing, 100083, China; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture, P.R, Beijing, 100083, China.
Beijing Jintian Mai International Food Co., Ltd, Beijing, 101407, China.
出版信息
Regul Toxicol Pharmacol. 2019 Apr;103:292-300. doi: 10.1016/j.yrtph.2019.02.005. Epub 2019 Feb 7.
A 90-day subchronic toxicology screen of genetically modified (GM) rice Lac-3 expressing human lactoferrin (hLF) and its effects on the gut microbiota were studied in comparison to non-GM rice fed to Sprague-Dawley (SD) rats. Three different dietary concentrations (17.5%, 35% and 70%, w/w) of the GM rice or its corresponding non-GM rice were used. Additionally, the phylotypes of gut microbiota in the control group, the 70% GM rice diet group and the 70% non-GM rice diet group on day 90 were determined by 16S rRNA sequencing. The results of the 90-day subchronic feeding study demonstrated that the GM rice Lac-3 containing human lactoferrin (LF) gene is considered as safe as the non-GM rice. The results of bacterial 16S rRNA sequencing showed that the structure of gut microbiota in the 70% GM group slightly changed when compared with the control group and the 70% non-GM group. There were no significant differences in the microbiota diversity among the three groups.
研究了表达人乳铁蛋白（hLF）的转基因（GM）水稻 Lac-3 的 90 天亚慢性毒理学筛选及其对肠道微生物群的影响，并与喂食给 Sprague-Dawley（SD）大鼠的非 GM 水稻进行了比较。使用了三种不同的 GM 水稻或其相应的非 GM 水稻的饮食浓度（17.5％，35％和 70％，w / w）。此外，通过 16S rRNA 测序确定了对照组、70％GM 水稻饮食组和 70％非 GM 水稻饮食组第 90 天的肠道微生物群的菌型。90 天亚慢性喂养研究的结果表明，含有人乳铁蛋白（LF）基因的 GM 水稻 Lac-3 被认为与非 GM 水稻一样安全。细菌 16S rRNA 测序的结果表明，与对照组和 70％非 GM 组相比，70％GM 组的肠道微生物群结构略有变化。三组之间的微生物多样性没有差异。
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