Darby Trevor M, Owens Joshua A, Saeedi Bejan J, Luo Liping, Matthews Jason D, Robinson Brian S, Naudin Crystal R, Jones Rheinallt M
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, 615 Michael Street, Atlanta GA 30322, USA.
Department of Pathology, Emory University School of Medicine, Atlanta GA 30322, USA.
iScience. 2019 Feb 22;12:356-367. doi: 10.1016/j.isci.2019.01.030. Epub 2019 Jan 29.
The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium that protects against tissue damage and injury-induced inflammation in the gut. We first employed the Drosophila animal model to screen for the capacity of candidate beneficial bacteria to protect the fly gut against injury. From this screen, we identified Lactococcus lactis subsp. cremoris as a bacterium that elicited potent cytoprotective activity. Then, in a murine model, we demonstrated that the same strain confers powerful cytoprotective influences against radiological damage, as well as anti-inflammatory activity in a gut colitis model. In summary, we demonstrate the positive salutary effects of a beneficial bacterium, namely, L. lactis subsp. cremoris on intestinal tissue and propose the use of this strain as a therapeutic to promote intestinal health.
使用有益细菌促进健康的做法已广泛应用。然而，证实此类宣称所推广细菌功效的实验证据仍然有限。我们通过鉴定一种可预防肠道组织损伤和损伤诱导炎症的有益细菌来填补这一空白。我们首先利用果蝇动物模型筛选候选有益细菌保护果蝇肠道免受损伤的能力。通过该筛选，我们鉴定出乳酸乳球菌乳脂亚种具有强大的细胞保护活性。然后，在小鼠模型中，我们证明同一菌株对放射性损伤具有强大的细胞保护作用，并在肠道结肠炎模型中具有抗炎活性。总之，我们证明了一种有益细菌，即乳酸乳球菌乳脂亚种对肠道组织具有积极有益的作用，并提议将该菌株用作促进肠道健康的治疗剂。
