Ludvigsson J, Forsberg P, Frydèn A, Lindblom B, Marshall M O, von Schenck H
Department of Pediatrics, Faculty of Health Sciences, Linköping University, Sweden.
Diabetes Res. 1988 Dec;9(4):193-5.
Mumps epidemics are followed by sporadic cases of insulin dependent diabetes mellitus (IDDM). We have studied beta-cell function in 11 subjects who had had a mumps infection. They had no clinical pancreatitis but were selected as they had abnormal pancreas iso-amylase values and/or glucosuria during the mumps virus infection. At the follow-up some years later the subjects were healthy. A few HbA1-values were noted in the upper part of the normal range. Total serum insulin values were normal, but the C-peptide values were low at first follow-up 1-3 years after infection in all but two patients. These values increased in 4/7 patients during the follow-up period but were subnormal in five subjects still 3-6 years after the infection. All five patients had HLA-DR 3 and/or 4. In 7 out of 11 patients islet cell surface antibodies could be demonstrated. Our results indicate that subclinical mumps pancreatitis may initiate a reaction towards the beta-cells recognized as subnormal C-peptide levels several years later in certain patients. This might contribute to manifest IDDM many years after infection.
腮腺炎流行之后会出现散发性胰岛素依赖型糖尿病（IDDM）病例。我们对11名曾感染过腮腺炎的受试者的β细胞功能进行了研究。他们没有临床胰腺炎，但因在腮腺炎病毒感染期间胰腺异淀粉酶值异常和/或出现糖尿而被选中。几年后的随访中，这些受试者身体健康。少数糖化血红蛋白（HbA1）值处于正常范围的上限。血清胰岛素总值正常，但除两名患者外，所有患者在感染后1至3年的首次随访时C肽值较低。在随访期间，4/7的患者这些值有所升高，但在感染后3至6年仍有5名受试者的值低于正常水平。所有这5名患者都有HLA - DR 3和/或4。11名患者中有7名可检测到胰岛细胞表面抗体。我们的结果表明，亚临床腮腺炎胰腺炎可能引发针对β细胞的反应，在某些患者中数年后表现为C肽水平低于正常。这可能导致感染多年后出现显性IDDM。
