血清铁蛋白作为非酒精性脂肪性肝病的生物标志物：准备好进入黄金时代了吗？ - Suppr

Serum ferritin as a biomarker for NAFLD: ready for prime time?

作者信息

Shah Raj A, Kowdley Kris V

机构信息

Liver Care Network and Organ Care Research, Swedish Medical Center, 1124 Columbia Street, Suite 600, Seattle, WA, 98104, USA.

出版信息

Hepatol Int. 2019 Mar;13(2):110-112. doi: 10.1007/s12072-019-09934-7. Epub 2019 Feb 9.

DOI:10.1007/s12072-019-09934-7

PMID:30739262

Abstract

摘要

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Serum ferritin as a biomarker for NAFLD: ready for prime time?血清铁蛋白作为非酒精性脂肪性肝病的生物标志物：准备好进入黄金时代了吗？

Hepatol Int. 2019 Mar;13(2):110-112. doi: 10.1007/s12072-019-09934-7. Epub 2019 Feb 9.

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population.血清铁蛋白水平与韩国普通人群的肝脂肪变性和纤维化有关。

Hepatol Int. 2019 Mar;13(2):222-233. doi: 10.1007/s12072-018-9892-8. Epub 2018 Sep 4.

Serum ferritin levels predict histological severity in patients with nonalcoholic fatty liver disease in India.血清铁蛋白水平可预测印度非酒精性脂肪性肝病患者的组织学严重程度。

Indian J Gastroenterol. 2015 May;34(3):200-8. doi: 10.1007/s12664-015-0572-5. Epub 2015 Jun 25.

Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women.绝经后女性血清铁蛋白水平与非酒精性脂肪性肝病的关联

Climacteric. 2018 Oct;21(5):509-514. doi: 10.1080/13697137.2018.1493451. Epub 2018 Aug 14.

The association between serum ferritin level, microalbuminuria and non-alcoholic fatty liver disease in non-diabetic, non-hypertensive men.血清铁蛋白水平、微量白蛋白尿与非糖尿病、非高血压男性非酒精性脂肪性肝病的关系。

Clin Exp Hypertens. 2014;36(6):380-5. doi: 10.3109/10641963.2013.827704. Epub 2013 Sep 18.

Elevated serum ferritin is associated with increased mortality in non-alcoholic fatty liver disease after 16 years of follow-up.血清铁蛋白升高与非酒精性脂肪性肝病 16 年随访后的死亡率升高相关。

Liver Int. 2016 Nov;36(11):1688-1695. doi: 10.1111/liv.13144. Epub 2016 Apr 28.

Association of serum ferritin with non-alcoholic fatty liver disease: a meta-analysis.血清铁蛋白与非酒精性脂肪性肝病的关系：一项荟萃分析。

Lipids Health Dis. 2017 Dec 2;16(1):228. doi: 10.1186/s12944-017-0613-4.

Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease.生长分化因子 15 可预测经活检证实的非酒精性脂肪性肝病的肝纤维化进展。

Liver Int. 2018 Apr;38(4):695-705. doi: 10.1111/liv.13587. Epub 2017 Sep 30.

The development of a non-invasive model to predict the presence of non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease.一种用于预测非酒精性脂肪性肝病患者非酒精性脂肪性肝炎存在情况的非侵入性模型的开发。

J Gastroenterol Hepatol. 2016 May;31(5):995-1000. doi: 10.1111/jgh.13235.

Hemoglobin combined with triglyceride and ferritin in predicting non-alcoholic fatty liver.血红蛋白联合甘油三酯和铁蛋白预测非酒精性脂肪肝

J Gastroenterol Hepatol. 2014;29(7):1508-14. doi: 10.1111/jgh.12580.

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From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients.从肠道到肝脏：揭示非酒精性脂肪性肝病（NAFL）和非酒精性脂肪性肝炎（NASH）患者肠道微生物群的差异

Front Microbiol. 2024 Apr 4;15:1366744. doi: 10.3389/fmicb.2024.1366744. eCollection 2024.

Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism.评估血清铜蓝蛋白是否通过调节铁代谢来促进非酒精性脂肪性肝炎。

J Med Biochem. 2023 Jan 20;42(1):113-121. doi: 10.5937/jomb0-37597.

The Gut Microbiome and Ferroptosis in MAFLD.非酒精性脂肪性肝病中的肠道微生物群与铁死亡

J Clin Transl Hepatol. 2023 Feb 28;11(1):174-187. doi: 10.14218/JCTH.2022.00136. Epub 2022 Jul 14.

Therapeutic Effect of Crocin on the NASH Model by Targeting the Fas Receptor Signaling Pathway.西红花苷通过靶向 Fas 受体信号通路对 NASH 模型的治疗作用。

Turk J Gastroenterol. 2022 Jun;33(6):505-514. doi: 10.5152/tjg.2022.21088.

MAFLD/NAFLD Biopsy-Free Scoring Systems for Hepatic Steatosis, NASH, and Fibrosis Diagnosis.用于肝脂肪变性、非酒精性脂肪性肝炎和肝纤维化诊断的MAFLD/NAFLD无创评分系统

Front Med (Lausanne). 2022 Jan 13;8:774079. doi: 10.3389/fmed.2021.774079. eCollection 2021.

Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia.血清铁蛋白水平升高可有效鉴别 2019 冠状病毒病肺炎的严重程度和肝损伤。

Biomarkers. 2021 May;26(3):207-212. doi: 10.1080/1354750X.2020.1861098. Epub 2021 Feb 10.

Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study.血清铁蛋白联合丙氨酸氨基转移酶和血糖水平对非酒精性脂肪性肝病进行无创评估的预测价值：肥胖症中的脂肪肝（FLiO）研究

Diagnostics (Basel). 2020 Nov 8;10(11):917. doi: 10.3390/diagnostics10110917.

Efficacy of Hijamat (wet cupping therapy) in Iranian patients with nonalcoholic fatty liver disease: a controlled clinical trial.Hijamat（湿拔罐疗法）治疗非酒精性脂肪性肝病伊朗患者的疗效：一项对照临床试验。

Turk J Med Sci. 2020 Apr 9;50(2):354-359. doi: 10.3906/sag-1907-82.

Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000 analyzer in Chinese adults.用间接法在雅培Architect i2000 分析仪上测定中国成年人血清铁蛋白的参考区间。

J Clin Lab Anal. 2020 Mar;34(3):e23083. doi: 10.1002/jcla.23083. Epub 2019 Nov 1.

Association between Different Animal Protein Sources and Liver Status in Obese Subjects with Non-Alcoholic Fatty Liver Disease: Fatty Liver in Obesity (FLiO) Study.不同动物蛋白来源与非酒精性脂肪性肝病肥胖患者肝脏状态的关系：肥胖相关性脂肪肝研究（FLiO 研究）。

Nutrients. 2019 Oct 3;11(10):2359. doi: 10.3390/nu11102359.

本文引用的文献

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population.血清铁蛋白水平与韩国普通人群的肝脂肪变性和纤维化有关。

Hepatol Int. 2019 Mar;13(2):222-233. doi: 10.1007/s12072-018-9892-8. Epub 2018 Sep 4.

Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.全球视角下的非酒精性脂肪性肝病和非酒精性脂肪性肝炎。

Hepatology. 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251.

Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis.铁过载触发严重酒精性肝炎中 ADAM-17 介导的炎症。

Sci Rep. 2018 Jul 6;8(1):10264. doi: 10.1038/s41598-018-28483-x.

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.非酒精性脂肪性肝病的诊断与管理：美国肝病研究协会的实践指南

Hepatology. 2018 Jan;67(1):328-357. doi: 10.1002/hep.29367. Epub 2017 Sep 29.

Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis.比较实验室检查、超声或磁共振弹性成像在非酒精性脂肪性肝病患者中检测纤维化的价值：一项荟萃分析。

Hepatology. 2017 Nov;66(5):1486-1501. doi: 10.1002/hep.29302. Epub 2017 Sep 26.

The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease.巨噬细胞活化标志物 sCD163 与非酒精性脂肪性肝病患者的形态学疾病分期相关。

Liver Int. 2016 Oct;36(10):1549-57. doi: 10.1111/liv.13150. Epub 2016 May 12.

EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease.欧洲肝脏研究学会-欧洲糖尿病研究学会-欧洲肥胖症研究学会非酒精性脂肪性肝病管理临床实践指南

J Hepatol. 2016 Jun;64(6):1388-402. doi: 10.1016/j.jhep.2015.11.004. Epub 2016 Apr 7.

Reference Intervals of Fibrosis Index Based on Four Indicators in Healthy Elderly Chinese.中国健康老年人基于四项指标的纤维化指数参考区间

J Clin Lab Anal. 2016 Sep;30(5):645-8. doi: 10.1002/jcla.21916. Epub 2016 Mar 8.

Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance.非酒精性脂肪性肝病中的肝纤维化——具有预后意义的诊断挑战

World J Gastroenterol. 2015 Oct 21;21(39):11077-87. doi: 10.3748/wjg.v21.i39.11077.

Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA.非侵入性评分可识别超声诊断的非酒精性脂肪性肝病并预测美国人群的死亡率。

BMC Med. 2014 Sep 10;12:154. doi: 10.1186/s12916-014-0154-x.

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Serum ferritin as a biomarker for NAFLD: ready for prime time?

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